Document Detail

Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis.
MedLine Citation:
PMID:  19767158     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Describe cerebrospinal fluid parameters in infants with culture-proven Group B streptococcal meningitis in the era of intrapartum antibiotic prophylaxis.
STUDY DESIGN: Cohort study of the first lumbar puncture from 13,495 infants cared for at 150 neonatal intensive care units. We compared cerebrospinal fluid parameters [white blood cell count, red blood cell count, glucose, and protein], demographics, and outcomes between infants with and without Group B streptococcal meningitis.
RESULTS: We identified 46 infants with Group B streptococcal meningitis. The median cerebrospinal fluid white blood cell count was 271 cells/mm(3) for infants with Group B streptococcal meningitis and 6 cells/mm(3) for infants without meningitis (p=0.0001). Of the infants with Group B streptococcal meningitis, 9/46 (20%) had negative blood cultures. Meningitis complicated 22/145 (15%) of episodes of early-onset Group B streptococcal sepsis and 13/23 (57%) of episodes of late-onset Group B streptococcal sepsis.
CONCLUSIONS: Group B streptococcal meningitis occurs in the presence of negative blood cultures. In hospitalized infants who undergo a lumbar puncture, Group B streptococcal sepsis is frequently complicated by GBS meningitis.
Annette K Ansong; P Brian Smith; Daniel K Benjamin; Reese H Clark; Jennifer S Li; C Michael Cotten; Barry Mangum; Harmony P Garges; Daniel K Benjamin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2009-09-19
Journal Detail:
Title:  Early human development     Volume:  85     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-02-12     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S5-7     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis*
Bacteremia / cerebrospinal fluid,  complications,  microbiology
Cerebrospinal Fluid / cytology,  microbiology
Cerebrospinal Fluid Proteins / analysis
Cohort Studies
Erythrocyte Count
Glucose / cerebrospinal fluid
Infant, Newborn
Leukocyte Count
Meningitis, Bacterial / cerebrospinal fluid*,  complications,  diagnosis,  microbiology
Spinal Puncture
Streptococcal Infections / cerebrospinal fluid*,  complications,  diagnosis,  microbiology
Streptococcus agalactiae / isolation & purification
Grant Support
1K24HD058735-01/HD/NICHD NIH HHS; 1R01FD003519-01/FD/FDA HHS; 1R01HD057956-02/HD/NICHD NIH HHS; 1U10-HD45962-06/HD/NICHD NIH HHS; K24 HD058735/HD/NICHD NIH HHS; K24 HD058735-01A1/HD/NICHD NIH HHS; UL1 RR024128/RR/NCRR NIH HHS; UL1 RR024128-02/RR/NCRR NIH HHS
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cerebrospinal Fluid Proteins; IY9XDZ35W2/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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