| Group B Streptococcus and pregnancy: a review. | |
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MedLine Citation:
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PMID: 18201679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the 1960s, early onset neonatal sepsis caused by group B Streptococcus (GBS) had an attack rate of 2 per 1000 live births and a 50% fatality rate. Early treatment and then antibiotic prophylaxis were shown to reduce morbidity and mortality rates; however, GBS remains a leading cause of perinatal infection. This article will review our investigations and related studies, including our studies in monkeys, that have contributed to current diagnosis, treatment, and prevention of disease caused by GBS. Although it has not been possible to eradicate GBS colonization, intravenous antibiotic prophylaxis given during parturition has been effective in the prevention of vertical transmission in animals and humans. Recently, diagnostic tests with polymerase chain reaction have offered promise for rapid accurate detection. This could lead to a major shift in the timing of diagnosis from the office setting to delivery suite. The potential for immunization remains a challenge. |
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Authors:
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John W Larsen; John L Sever |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-01-16 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 198 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-05-27 Revised Date: 2009-01-22 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 440-8; discussion 448-50 Citation Subset: AIM; IM |
Affiliation:
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The George Washington University, Washington, DC, USA. jlarsen@mfa.gwu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibiotic Prophylaxis Female Humans Infant, Newborn Infectious Disease Transmission, Vertical / prevention & control* Macaca mulatta Pregnancy Pregnancy Complications, Infectious / diagnosis*, drug therapy, microbiology, prevention & control Sepsis / drug therapy*, microbiology* Streptococcal Infections / diagnosis*, drug therapy, microbiology, prevention & control Streptococcus agalactiae / isolation & purification* |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 2008 Dec;199(6):e14; author reply e14-5
[PMID:
18667189
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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