| Group B Streptococcus colonization during pregnancy and maternal-fetal transmission in Zimbabwe. | |
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MedLine Citation:
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PMID: 19916889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To explore risk factors for group B Streptococcus (GBS) colonization during pregnancy and at delivery, estimate the predictive value of early GBS colonization for colonization at delivery and in the newborn, and explore the relationship to adverse perinatal factors. DESIGN AND SETTING: Cohort study of pregnant women from three communities in Zimbabwe. METHODS: Information collected by questionnaire at inclusion and from delivery records. Vaginal and rectal swabs collected for GBS culture at 20 and 26 weeks gestation, at delivery and from the newborn infant. MAIN OUTCOME MEASURES: GBS colonization in pregnancy, colonization of mother and newborn, and perinatal factors. RESULTS: GBS culture results were obtained at one or more occasion for 780 (75.2%) of 1,037 women recruited. Altogether, 470/780 women (60.3%) tested positive for GBS, with colonization rates at 20, 26 weeks and delivery of 47%, 24.2% and 21%, respectively. Positive GBS culture at 20 and 26 weeks gestation had a low positive predictive value on colonization at delivery and in the newborn. Women living in rural areas were significantly more often colonized than those who lived in urban areas (p < 0.001). Other socio-economic, demographic and obstetric factors were not statistically associated with GBS colonization. GBS transmission was not statistically significantly associated with adverse perinatal outcomes. CONCLUSIONS: GBS colonization was common among pregnant women in Zimbabwe. Dwelling in a rural area was significantly associated with GBS colonization while other risk factors were not. Early GBS colonization had a low predictive value for colonization at delivery and colonization was not associated with adverse perinatal outcome. |
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Authors:
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Rooyen T Mavenyengwa; Jan Egil Afset; Berit Schei; Synn?ve Berg; Tone Caspersen; H?kon Bergseng; Sylvester R Moyo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 89 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-03-04 Revised Date: 2010-04-07 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: England |
Other Details:
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Languages: eng Pagination: 250-5 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, University of Zimbabwe College of Health Sciences (UZ), Harare, Zimbabwe. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Cohort Studies Delivery, Obstetric Female Gestational Age Humans Infant, Newborn Infectious Disease Transmission, Vertical Meconium Predictive Value of Tests Pregnancy Pregnancy Complications, Infectious / epidemiology, microbiology* Risk Factors Rural Population Streptococcal Infections / epidemiology, transmission* Streptococcus agalactiae* Urban Population Zimbabwe / epidemiology |
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