Document Detail

Group B Streptococcus and Escherichia coli infections in the intensive care nursery in the era of intrapartum antibiotic prophylaxis.
MedLine Citation:
PMID:  23011013     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Group B Streptococcus (GBS) and Escherichia coli cause serious bacterial infections (SBIs) and are associated with morbidity and mortality in newborn infants. Intrapartum antibiotic prophylaxis reduces early-onset SBIs caused by GBS. The effect of intrapartum antibiotic prophylaxis on late-onset SBIs caused by these organisms is unknown.
METHODS: We examined all blood, urine and cerebrospinal fluid culture results from infants admitted from 1997 to 2010 to 322 neonatal intensive care units managed by the Pediatrix Medical Group. We identified infants with positive cultures for GBS or E. coli and compared the incidence of early- and late-onset SBI for each organism in the time period before (1997 to 2001) and after (2002 to 2010) universal intrapartum antibiotic prophylaxis recommendations.
RESULTS: We identified 716,407 infants with cultures, 2520 (0.4%) with cultures positive for GBS and 2476 (0.3%) with cultures positive for E. coli. The incidence of GBS early-onset SBI decreased between 1997 to 2001 and 2002 to 2010 from 3.5 to 2.6 per 1000 admissions, and the incidence for E. coli early-onset SBI remained stable (1.4/1000 admissions in both time periods). Over the same time period, the incidence of GBS late-onset SBI increased from 0.8 to 1.1 per 1000 admissions, and incidence of E. coli late-onset SBI increased from 2.2 to 2.5 per 1000 admissions.
CONCLUSIONS: In our cohort, the incidence of GBS early-onset SBI decreased, whereas the incidence of late-onset SBI for E. coli and GBS increased.
Melissa S Bauserman; Matthew M Laughon; Christoph P Hornik; P Brian Smith; Daniel K Benjamin; Reese H Clark; Cyril Engmann; Michael Cohen-Wolkowiez
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  32     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2013-09-19     Revised Date:  2014-03-27    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  208-12     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*
Antibiotic Prophylaxis / methods*
Blood / microbiology
Cerebrospinal Fluid / microbiology
Cohort Studies
Escherichia coli / isolation & purification*
Escherichia coli Infections / epidemiology*,  microbiology
Infant, Newborn
Intensive Care Units, Neonatal
Retrospective Studies
Streptococcal Infections / epidemiology*,  microbiology
Streptococcus agalactiae / isolation & purification*
Urine / microbiology
Grant Support
1K23HD060040-01/HD/NICHD NIH HHS; 1K23HD064814-01/HD/NICHD NIH HHS; 1K23HL092225-01/HL/NHLBI NIH HHS; 1K24HD058735-01/HD/NICHD NIH HHS; 1R01FD003519-01/FD/FDA HHS; 1R01HD057956-02/HD/NICHD NIH HHS; 1R18AE000028-01/AE/ASPE HHS; 1U10-HD45962-06/HD/NICHD NIH HHS; HHSN267200700051C//PHS HHS; K23 HD060040/HD/NICHD NIH HHS; K23 HD068497/HD/NICHD NIH HHS; K24 HD058735/HD/NICHD NIH HHS; L40 HD069892/HD/NICHD NIH HHS
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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