Document Detail

Group B Streptococcal Colonization in 160 Mother-Baby Pairs: A Prospective Cohort Study.
MedLine Citation:
PMID:  23866714     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To identify the source of postnatal colonization with group B Streptococcus (GBS) and to evaluate the impact of intrapartum antibiotic prophylaxis (IAP) administration in newborn infant transmission.
STUDY DESIGN: A prospective, longitudinal study evaluated GBS colonization in 160 mother-baby pairs. Specimens were collected from the time of delivery to 8 weeks post-partum, from rectum, vagina, and milk of mothers, and from throat and rectum of neonates. Women were grouped according to their GBS status at discharge from the hospital: culture-positive carriers (n = 83), culture-negative carriers (n = 26), and noncarriers (n = 51). Newborns were considered colonized if GBS was yielded from at least 1 site.
RESULTS: A total of 35 (21.9%) neonates were colonized; 30 were born to culture-positive carriers, 2 to culture-negative carriers, and 3 to noncarriers. Infants of culture-positive carriers exposed to IAP were less likely to be colonized (15/57 vs 15/26, P = .01), or heavily colonized, (7/57 vs 9/26, P = .04). Of all newborns, those exposed to IAP and discharged GBS-free from hospital, often became colonized subsequently (12/57 vs 1/26, P = .09). Molecular typing analysis (available for 30 of 32 carrier mothers and their infants) confirmed an identical strain of GBS in all mother-baby pairs. Six of 83 culture-positive carrier mothers had a positive milk culture. Their respective neonates all were heavily colonized.
CONCLUSIONS: Newborns exposed to IAP and GBS-free at hospital discharge subsequently acquire GBS from their mothers. Culture-positive milk is associated with heavy neonatal colonization.
Alberto Berardi; Cecilia Rossi; Roberta Creti; Mariachiara China; Giovanni Gherardi; Claudia Venturelli; Fabio Rumpianesi; Fabrizio Ferrari
Related Documents :
24532064 - Altered fecal microbiota composition for food allergy in infants.
874674 - Possible urate nephropathy of the newborn infant as a cause of transient renal insuffic...
8260554 - Influence of nacl supplementation on vasopressin secretion and water excretion in prema...
402034 - A study of the plasma free amino acids in infants of low birth weight, with a compariso...
21397814 - Reversible retinal edema in an infant with neonatal hemochromatosis and liver failure.
24637604 - New insights into the hygiene hypothesis in allergic diseases: mediation of sibling and...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-15
Journal Detail:
Title:  The Journal of pediatrics     Volume:  -     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
Neonatal Intensive Care Unit, Polyclinic University Hospital, Modena, Italy. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  [Research update of anti-TNF-? biologic agents in the treatment of uveitis].
Next Document:  Oral Corticosteroids and Onset of Cardiomyopathy in Duchenne Muscular Dystrophy.