Document Detail


Group 1 CD1-restricted T cells take center stage.
MedLine Citation:
PMID:  21341260     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The recognition of lipid antigens by T cells is a complex and fascinating phenomenon. The MHC-like molecules of the CD1 family have evolved to present a wide variety of both self and foreign lipids for recognition by T-cell receptors. While much progress has been made in our understanding of the NKT cells that recognize lipids presented by CD1d molecules, our knowledge of the T-cell populations directed at the related group 1 CD1 molecules, i.e. CD1a, CD1b and CD1c, has lagged behind. In this issue of the European Journal of Immunology, a study identifies a surprisingly large portion of human peripheral blood T cells as being autoreactive to the group 1 CD1 proteins. This work and other recent developments highlight the presence of a substantial number of unconventional T cells as part of our normal T-cell repertoire. This interesting finding is discussed in details in this commentary.
Authors:
Mary H Young; Laurent Gapin
Publication Detail:
Type:  Journal Article     Date:  2011-02-11
Journal Detail:
Title:  European journal of immunology     Volume:  41     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  592-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Integrated Department of immunology, University of Colorado School of Medicine, National Jewish Health, Denver, CO, USA.
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