| Group 1 CD1-restricted T cells take center stage. | |
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MedLine Citation:
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PMID: 21341260 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The recognition of lipid antigens by T cells is a complex and fascinating phenomenon. The MHC-like molecules of the CD1 family have evolved to present a wide variety of both self and foreign lipids for recognition by T-cell receptors. While much progress has been made in our understanding of the NKT cells that recognize lipids presented by CD1d molecules, our knowledge of the T-cell populations directed at the related group 1 CD1 molecules, i.e. CD1a, CD1b and CD1c, has lagged behind. In this issue of the European Journal of Immunology, a study identifies a surprisingly large portion of human peripheral blood T cells as being autoreactive to the group 1 CD1 proteins. This work and other recent developments highlight the presence of a substantial number of unconventional T cells as part of our normal T-cell repertoire. This interesting finding is discussed in details in this commentary. |
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Authors:
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Mary H Young; Laurent Gapin |
Publication Detail:
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Type: Journal Article Date: 2011-02-11 |
Journal Detail:
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Title: European journal of immunology Volume: 41 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 592-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Integrated Department of immunology, University of Colorado School of Medicine, National Jewish Health, Denver, CO, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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