Document Detail


Gross placental structure in a low-risk population of singleton, term, first-born infants.
MedLine Citation:
PMID:  19007303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Suboptimal fetal growth has been associated with an increased risk of adult disease, which may be exacerbated by an increased placental weight-to-fetal weight ratio. Placental weight is a summary measure of placental growth and development throughout pregnancy. However, measures of placental structure, including the chorionic disk surface area and thickness and eccentricity of the umbilical cord insertion, have been shown to account for additional variance in birth weight beyond that explained by placental weight. Little is known of the variability of these placental parameters in low-risk populations; their association with maternal, pregnancy, and neonatal characteristics; and the agreement between manual and digital measures. This study used manual and digital image analysis techniques to examine gross placental anatomy in 513 low-risk, singleton, term, first-born infants. Parametric methods compared groups and examined relationships among variables. Maternal birth weight, prepregnancy weight, and body mass index were associated with increased placental and birth weight (all P < 0.005), but only maternal birth weight was associated with increased placental surface area (P < 0.0005) and thickness (P = 0.005). Smoking during pregnancy reduced birth weight and increased the eccentricity of umbilical cord insertion (P = 0.012 and 0.034, respectively). The variability in these placental parameters was consistently lower than that reported in the literature, and correlations between digital and manual measurements were reasonable (r = .87-.71). Detailed analyses of gross placental structure can provide biologically relevant information regarding placental growth and development and, potentially, their consequences.
Authors:
David A Coall; Adrian K Charles; Carolyn M Salafia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  12     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-09-07     Completed Date:  2009-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-10     Citation Subset:  IM    
Affiliation:
Center for Cognitive and Decision Sciences, Institute of Psychology, University of Basel, Missionsstrasse 64a, 4055 Basel, Switzerland. david.coall@unibas.ch
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Birth Weight / physiology*
Body Mass Index
Female
Gestational Age
Humans
Image Processing, Computer-Assisted
Infant, Newborn
Male
Middle Aged
Organ Size / physiology
Parity / physiology*
Placenta / anatomy & histology*,  physiology
Pregnancy
Reproducibility of Results
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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