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Gross intestinal adaptations in relation to broiler performance during chronic aflatoxin exposure.
MedLine Citation:
PMID:  21753204     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The present trial was conducted to study some morphological, digestive, and electrophysiological variables of the small intestine during chronic exposure of broilers to aflatoxin B(1) (AFB(1)). Ross 308 male chicks (7 d old) were randomly allotted to control (no AFB(1)), low AFB(1) (0.07 mg of AFB(1)/kg), or high AFB(1) (0.75 mg of AFB(1)/kg) diet. The high AFB(1) diet resulted in reduced (P ≤ 0.002) bird performance during the first 4 wk of exposure, whereas the low AFB(1) diet temporarily reduced (P = 0.034) the bird performance during wk 3 of exposure. During wk 4 of exposure, a linear (P ≤ 0.013) decrease in the unit weight of both the duodenum and jejunum was observed with increasing levels of AFB(1). This reduction in unit weight appeared to progress from the proximal (duodenum) to the distal (jejunum) small intestine with increase in the length of exposure and was not accompanied by modulation of electrophysiological variables in jejunal epithelium. Response from amiloride, a specific blocker of epithelial sodium channel, was also similar among jejunal epithelia of birds under different treatments. Interestingly, a compensatory linear (P ≤ 0.002) increase in the length of the duodenum and jejunum under high AFB(1) diets was noted to occur during wk 4 of exposure. Thus, retention of DM and nitrogen was not negatively affected by the AFB(1) diets. These data indicate that the intestine in broilers may adapt to an ongoing dietary challenge to AFB(1).
Authors:
A W Yunus; K Ghareeb; A A M Abd-El-Fattah; M Twaruzek; J Böhm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  90     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1683-9     Citation Subset:  IM    
Affiliation:
Institute of Animal Nutrition, Department for Farm Animal and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria;
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