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The Groningen LCPUFA Study: No Effect of Short Term Postnatal Long-Chain Polyunsaturated Fatty Acids in Healthy Term Infants on Cardiovascular and Anthropometric Development at 9 Years.
MedLine Citation:
PMID:  21705958     Owner:  NLM     Status:  Publisher    
Conflicting evidence exists on the effect of long-chain polyunsaturated fatty acid (LCPUFA) formula supplementation on cardiovascular health in term infants. It is known that LCPUFA supplementation does not affect infant growth, but long term outcome data are not available. The current study investigates whether two months LCPUFA formula supplementation affects cardiovascular and anthropometric development at 9 years. A prospective, double-blind, randomized trial was performed in healthy term infants: a standard formula control group (CF, n=169) and a LCPUFA-supplemented group (LF, n=145; 0.45% (by wt) AA and 0.30% (by wt) DHA). A breastfed group (BF; n=159) served as reference. At age 9, systolic and diastolic blood pressure, heart rate, head circumference, weight and height were measured. Univariate and multivariate analyses were performed. 63 to 79% of children were assessed. None of the cardiovascular or anthropometric measurements differed between the formula groups. Breastfed children had a marginally lower heart rate than formula fed children, in particular compared to children fed control formula. Blood pressure and parameters of growth including body mass index of breast and formula fed children did not differ. In conclusion, the study suggests that short term LCPUFA supplementation does not influence cardiovascular and anthropometric development at 9 years. ABBREVIATIONS:
Corina de Jong; Gunther Boehm; Hedwig K Kikkert; Mijna Hadders-Algra
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-23
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Paediatrics [C.J., H.K.K., M.H.-A.], University Medical Center Groningen, Groningen, 9700RB, The Netherlands; Danone Research [G.B.], Milupa GmbH, Friedrichsdorf, D-61381, Germany.
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