Document Detail

Grid cells and theta as oscillatory interference: theory and predictions.
MedLine Citation:
PMID:  19021256     Owner:  NLM     Status:  MEDLINE    
The oscillatory interference model [Burgess et al. (2007) Hippocampus 17:801-802] of grid cell firing is reviewed as an algorithmic level description of path integration and as an implementation level description of grid cells and their inputs. New analyses concern the relationships between the variables in the model and the theta rhythm, running speed, and the intrinsic firing frequencies of grid cells. New simulations concern the implementation of velocity-controlled oscillators (VCOs) with different preferred directions in different neurons. To summarize the model, the distance traveled along a specific direction is encoded by the phase of a VCO relative to a baseline frequency. Each VCO is an intrinsic membrane potential oscillation whose frequency increases from baseline as a result of depolarization by synaptic input from speed modulated head-direction cells. Grid cell firing is driven by the VCOs whose preferred directions match the current direction of motion. VCOs are phase-reset by location-specific input from place cells to prevent accumulation of error. The baseline frequency is identified with the local average of VCO frequencies, while EEG theta frequency is identified with the global average VCO frequency and comprises two components: the frequency at zero speed and a linear response to running speed. Quantitative predictions are given for the inter-relationships between a grid cell's intrinsic firing frequency and grid scale, the two components of theta frequency, and the running speed of the animal. Qualitative predictions are given for the properties of the VCOs, and the relationship between environmental novelty, the two components of theta, grid scale and place cell remapping.
Neil Burgess
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hippocampus     Volume:  18     ISSN:  1098-1063     ISO Abbreviation:  Hippocampus     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-02-27     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1157-74     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Wiley-Liss, Inc.
Institute of Cognitive Neuroscience, University College London.
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MeSH Terms
Action Potentials / physiology*
Biological Clocks / physiology*
Computer Simulation
Entorhinal Cortex / physiology*
Nerve Net / physiology*
Neurons / physiology*
Space Perception / physiology
Synaptic Transmission / physiology
Theta Rhythm*
Grant Support
G0501672//Medical Research Council; G0501672(76328)//Medical Research Council; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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