| Grey matter deficit in long-term recovered anorexia nervosa patients. | |
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MedLine Citation:
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PMID: 21038322 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Cerebral grey matter (GM) reduction has repeatedly been shown in anorexia nervosa (AN). Evidence concerning completeness of GM restitution in recovered patients is contradictory. METHODS: Five long-term recovered patients with AN were compared to symptomatic subjects and healthy controls using voxel-based morphometry. Whole brain GM, white matter and cerebrospinal fluid fractions were studied. Additionally, voxels that had shown significant GM reductions in symptomatic patients were investigated. RESULTS: Recovered subjects had been severely affected when symptomatic (mean body mass index: 12.1 kg/m²) and were in remission for a very long time period (>5 years). Whole brain tissue fractions did not differ from controls. Regional analysis showed persistent GM volume reduction, in particular of the precuneus. CONCLUSIONS: This study further supports the assumption that GM volume restitution is incomplete in subjects, who had previously been severely affected by anorexia nervosa. The meaning of GM reduction in long-term recovered AN patients, that is, its pathophysiological relevance, however, remains unclear. Furthermore, the precise aetiology of GM reduction remains an open question. |
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Authors:
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Andreas Joos; Armin Hartmann; Volkmar Glauche; Evgeniy Perlov; Thomas Unterbrink; Barbara Saum; Oliver Tüscher; Ludger Tebartz van Elst; Almut Zeeck |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European eating disorders review : the journal of the Eating Disorders Association Volume: 19 ISSN: 1099-0968 ISO Abbreviation: Eur Eat Disord Rev Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2010-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9436977 Medline TA: Eur Eat Disord Rev Country: England |
Other Details:
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Languages: eng Pagination: 59-63 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association. |
Affiliation:
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Department of Psychosomatic Medicine and Psychotherapy, University of Freiburg, Freiburg, Germany. andreas.joos@uniklinik-freiburg.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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