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Grey matter deficit in long-term recovered anorexia nervosa patients.
MedLine Citation:
PMID:  21038322     Owner:  NLM     Status:  In-Process    
OBJECTIVE: Cerebral grey matter (GM) reduction has repeatedly been shown in anorexia nervosa (AN). Evidence concerning completeness of GM restitution in recovered patients is contradictory.
METHODS: Five long-term recovered patients with AN were compared to symptomatic subjects and healthy controls using voxel-based morphometry. Whole brain GM, white matter and cerebrospinal fluid fractions were studied. Additionally, voxels that had shown significant GM reductions in symptomatic patients were investigated.
RESULTS: Recovered subjects had been severely affected when symptomatic (mean body mass index: 12.1 kg/m²) and were in remission for a very long time period (>5 years). Whole brain tissue fractions did not differ from controls. Regional analysis showed persistent GM volume reduction, in particular of the precuneus.
CONCLUSIONS: This study further supports the assumption that GM volume restitution is incomplete in subjects, who had previously been severely affected by anorexia nervosa. The meaning of GM reduction in long-term recovered AN patients, that is, its pathophysiological relevance, however, remains unclear. Furthermore, the precise aetiology of GM reduction remains an open question.
Andreas Joos; Armin Hartmann; Volkmar Glauche; Evgeniy Perlov; Thomas Unterbrink; Barbara Saum; Oliver Tüscher; Ludger Tebartz van Elst; Almut Zeeck
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European eating disorders review : the journal of the Eating Disorders Association     Volume:  19     ISSN:  1099-0968     ISO Abbreviation:  Eur Eat Disord Rev     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9436977     Medline TA:  Eur Eat Disord Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association.
Department of Psychosomatic Medicine and Psychotherapy, University of Freiburg, Freiburg, Germany.
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