Document Detail

Gregg's congenital rubella patients 60 years later.
MedLine Citation:
PMID:  12463994     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In 1941, a Sydney ophthalmologist, Norman McAlister Gregg, correctly identified the link between congenital cataracts in infants and maternal rubella early in pregnancy. Fifty of Gregg's subjects with congenital rubella, born in 1939-1944, were reviewed in 1967 and again in 1991. We reviewed this cohort in 2000-2001, 60 years after their intrauterine infection. METHODS: The subjects underwent full clinical assessment, plus pathology tests, an ophthalmological and cardiological review (including electrocardiography and echocardiography) and HLA histocompatibility testing. RESULTS: Since they were first seen in 1967, 10 have died (cardiovascular causes [4], malignant disease [4], AIDS [1], and hepatitis C-related cirrhosis [1]). All surviving men came for review (19) and 13 women (eight women declined). Echocardiography showed mild aortic valve sclerosis in 68%. The prevalence of diabetes (22%), thyroid disorders (19%), early menopause (73%) and osteoporosis (12.5%) was increased compared with the Australian population; 41% had undetectable levels of rubella antibodies. The frequency of HLA-A1 (44%) and HLA-B8 (34%) antigens was increased, and the haplotype HLA-A1, B8, DR3, said to be highly associated with many autoimmune conditions, was present in 25%. CONCLUSIONS: This cohort of people with congenital rubella has illuminated our understanding of viral teratogenesis.
Jill M Forrest; Fiona M Turnbull; Gary F Sholler; Richard E Hawker; Frank J Martin; Trevor T Doran; Margaret A Burgess
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Publication Detail:
Type:  Biography; Historical Article; Journal Article; Portraits    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  177     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:    2002 Dec 2-16
Date Detail:
Created Date:  2002-12-04     Completed Date:  2003-01-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  664-7     Citation Subset:  IM    
Royal Alexandra Hospital for Children, Locked Bag 4001, Westmead, NSW.
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MeSH Terms
Antibodies, Viral / analysis
Cardiovascular Diseases / complications
Cohort Studies
Diabetes Complications
Eye Diseases / complications
Follow-Up Studies
HLA Antigens / analysis
History, 20th Century
Infant, Newborn
Quality of Life
Rubella Syndrome, Congenital / complications,  diagnosis*,  history,  immunology
Rubella virus / immunology
Reg. No./Substance:
0/Antibodies, Viral; 0/HLA Antigens
Personal Name Subject
Personal Name Subject:
Norman McAlister Gregg

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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