| Gregg's congenital rubella patients 60 years later. | |
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MedLine Citation:
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PMID: 12463994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In 1941, a Sydney ophthalmologist, Norman McAlister Gregg, correctly identified the link between congenital cataracts in infants and maternal rubella early in pregnancy. Fifty of Gregg's subjects with congenital rubella, born in 1939-1944, were reviewed in 1967 and again in 1991. We reviewed this cohort in 2000-2001, 60 years after their intrauterine infection. METHODS: The subjects underwent full clinical assessment, plus pathology tests, an ophthalmological and cardiological review (including electrocardiography and echocardiography) and HLA histocompatibility testing. RESULTS: Since they were first seen in 1967, 10 have died (cardiovascular causes [4], malignant disease [4], AIDS [1], and hepatitis C-related cirrhosis [1]). All surviving men came for review (19) and 13 women (eight women declined). Echocardiography showed mild aortic valve sclerosis in 68%. The prevalence of diabetes (22%), thyroid disorders (19%), early menopause (73%) and osteoporosis (12.5%) was increased compared with the Australian population; 41% had undetectable levels of rubella antibodies. The frequency of HLA-A1 (44%) and HLA-B8 (34%) antigens was increased, and the haplotype HLA-A1, B8, DR3, said to be highly associated with many autoimmune conditions, was present in 25%. CONCLUSIONS: This cohort of people with congenital rubella has illuminated our understanding of viral teratogenesis. |
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Authors:
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Jill M Forrest; Fiona M Turnbull; Gary F Sholler; Richard E Hawker; Frank J Martin; Trevor T Doran; Margaret A Burgess |
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Publication Detail:
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Type: Biography; Historical Article; Journal Article; Portraits |
Journal Detail:
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Title: The Medical journal of Australia Volume: 177 ISSN: 0025-729X ISO Abbreviation: Med. J. Aust. Publication Date: 2002 Dec 2-16 |
Date Detail:
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Created Date: 2002-12-04 Completed Date: 2003-01-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0400714 Medline TA: Med J Aust Country: Australia |
Other Details:
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Languages: eng Pagination: 664-7 Citation Subset: IM |
Affiliation:
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Royal Alexandra Hospital for Children, Locked Bag 4001, Westmead, NSW. jillf@chw.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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analysis Australia Cardiovascular Diseases / complications Cohort Studies Diabetes Complications Eye Diseases / complications Female Follow-Up Studies HLA Antigens / analysis History, 20th Century Humans Infant, Newborn Male Quality of Life Rubella Syndrome, Congenital / complications, diagnosis*, history, immunology Rubella virus / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/HLA Antigens |
| Personal Name Subject | |
Personal Name Subject:
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Norman McAlister Gregg |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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