| Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans. | |
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MedLine Citation:
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PMID: 20041649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following the ingestion of green tea, substantial quantities of flavan-3-ols pass from the small to the large intestine (Stalmach et al. Mol. Nutr. Food Res. 2009, 53, S44-S53; Mol. Nutr. Food Res. 2009, doi: 10.1002/mnfr.200900194). To investigate the fate of the flavan-3-ols entering the large intestine, where they are subjected to the action of the colonic microflora, (-)-epicatechin, (-)-epigallocatechin, and (-)-epigallocatechin-3-O-gallate were incubated in vitro with fecal slurries and the production of phenolic acid catabolites was determined by GC-MS. In addition, urinary excretion of phenolic catabolites was investigated over a 24 h period after ingestion of either green tea or water by healthy volunteers with a functioning colon. The green tea was also fed to ileostomists, and 0-24 h urinary excretion of phenolic acid catabolites was monitored. Pathways are proposed for the degradation of green tea flavan-3-ols in the colon and further catabolism of phenolic compounds passing into the circulatory system from the large intestine, prior to urinary excretion in quantities corresponding to ca. 40% of intake compared with ca. 8% absorption of flavan-3-ol methyl, glucuronide, and sulfate metabolites in the small intestine. The data obtained point to the importance of the colonic microflora in the overall bioavailability and potential bioactivity of dietary flavonoids. |
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Authors:
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Suri Roowi; Angelique Stalmach; William Mullen; Michael E J Lean; Christine A Edwards; Alan Crozier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-20 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1296-304 Citation Subset: IM |
Affiliation:
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Plant Products and Human Nutrition Group, Graham Kerr Building, Division of Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Catechin / chemistry, metabolism Colon / chemistry, metabolism* Feces / chemistry, microbiology Female Flavonoids / chemistry, pharmacokinetics*, urine Humans Hydroxybenzoic Acids / analysis, metabolism Male Tea / chemistry*, metabolism Urinary Tract / chemistry, metabolism* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Flavonoids; 0/Hydroxybenzoic Acids; 0/Tea; 0/flavan-3-ol; 154-23-4/Catechin; 29656-58-4/phenolic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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