Document Detail


Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans.
MedLine Citation:
PMID:  20041649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following the ingestion of green tea, substantial quantities of flavan-3-ols pass from the small to the large intestine (Stalmach et al. Mol. Nutr. Food Res. 2009, 53, S44-S53; Mol. Nutr. Food Res. 2009, doi: 10.1002/mnfr.200900194). To investigate the fate of the flavan-3-ols entering the large intestine, where they are subjected to the action of the colonic microflora, (-)-epicatechin, (-)-epigallocatechin, and (-)-epigallocatechin-3-O-gallate were incubated in vitro with fecal slurries and the production of phenolic acid catabolites was determined by GC-MS. In addition, urinary excretion of phenolic catabolites was investigated over a 24 h period after ingestion of either green tea or water by healthy volunteers with a functioning colon. The green tea was also fed to ileostomists, and 0-24 h urinary excretion of phenolic acid catabolites was monitored. Pathways are proposed for the degradation of green tea flavan-3-ols in the colon and further catabolism of phenolic compounds passing into the circulatory system from the large intestine, prior to urinary excretion in quantities corresponding to ca. 40% of intake compared with ca. 8% absorption of flavan-3-ol methyl, glucuronide, and sulfate metabolites in the small intestine. The data obtained point to the importance of the colonic microflora in the overall bioavailability and potential bioactivity of dietary flavonoids.
Authors:
Suri Roowi; Angelique Stalmach; William Mullen; Michael E J Lean; Christine A Edwards; Alan Crozier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  58     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1296-304     Citation Subset:  IM    
Affiliation:
Plant Products and Human Nutrition Group, Graham Kerr Building, Division of Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Catechin / chemistry,  metabolism
Colon / chemistry,  metabolism*
Feces / chemistry,  microbiology
Female
Flavonoids / chemistry,  pharmacokinetics*,  urine
Humans
Hydroxybenzoic Acids / analysis,  metabolism
Male
Tea / chemistry*,  metabolism
Urinary Tract / chemistry,  metabolism*
Young Adult
Chemical
Reg. No./Substance:
0/Flavonoids; 0/Hydroxybenzoic Acids; 0/Tea; 0/flavan-3-ol; 154-23-4/Catechin; 29656-58-4/phenolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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