Document Detail

Green tea extract co-administered with a polymer effectively prevents alcoholic liver damage by prolonged inhibition of alcohol absorption in mice.
MedLine Citation:
PMID:  23136046     Owner:  NLM     Status:  MEDLINE    
AIMS: Alcohol toxicity can induce multiple organ dysfunction, including the liver. Gallated catechins (GCs), the components of green tea extract (GTE), have been known to inhibit intestinal lipid absorption. This study was designed to investigate the inhibitory effect of GC on the absorption of the lipid-soluble ethanol in normal mice. In addition, the effectiveness of prolonging the GC-mediated effect was evaluated as a means of preventing alcoholic liver damage.
METHODS: GTE was administered orally immediately or 90 min before ethanol administration and the blood ethanol and acetaldehyde levels were measured. Binge ethanol administration (by gavage every 6 h for 24 h) was used to induce acute liver injury, and GTE was administered 90 min prior to every ethanol administration.
RESULTS: When GTE, but not GC-decreased GTE, was administered immediately before ethanol intake, the blood ethanol and acetaldehyde levels were significantly lower than those in the control. On the other hand, GTE has no effect when GTE was administered 90 min before ethanol intake. When GTE was co-administered with polyethylene glycol (PEG) or poly-γ-glutamate (PGA) 90 min before ethanol intake, the lowering effect of GTE on the blood ethanol and acetaldehyde levels was maintained in contrast to the GTE-alone-treated group. After binge ethanol administration, liver weight decreased, and serum alanine aminotransferase and aspartate aminotransferase levels were elevated. Additionally, histopathological changes, such as macrovesicular steatosis and necrosis, were induced in the liver, together with reactive oxygen species generation. When GTE + PEG or GTE + PGA, but not GTE alone, was administered 90 min before ethanol intake, acute liver injury was ameliorated.
CONCLUSION: These findings support the development of GTE + PEG or GTE + PGA as an inhibitor of intestinal alcohol absorption for the preventative treatment of acute alcohol toxicity.
Jae-Hyung Park; Sun-Joo Kim; Ilseon Hwang; Ki-Cheor Bae; Jae-Hoon Bae; Dae-Kyu Song
Related Documents :
24589296 - Cluster and meta-analyses on factors influencing stress-induced alcohol drinking and re...
4051946 - Effect of adenosine and aicar on atp content and regional contractile function in reper...
18198996 - Ischemia-reperfusion induces inhibition of mitochondrial protein synthesis and cytochro...
14564606 - Effects of nitric oxide synthase inhibition on extracellular glutamate and cerebral blo...
3207986 - Vitamin k 2,3-epoxide reductase: the basis for stereoselectivity of 4-hydroxycoumarin a...
10397406 - Role of centrally administered melatonin and inhibitors of cox and nos in lps-induced h...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-07
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  48     ISSN:  1464-3502     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-09-19     Revised Date:  2013-12-02    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  England    
Other Details:
Languages:  eng     Pagination:  59-67     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Drug Therapy, Combination
Ethanol / antagonists & inhibitors,  metabolism*,  toxicity
Intestinal Absorption / drug effects*,  physiology
Liver Diseases, Alcoholic / metabolism*,  prevention & control*
Mice, Inbred C57BL
Plant Extracts / administration & dosage*,  isolation & purification
Polymers / administration & dosage*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Plant Extracts; 0/Polymers; 0/Tea; 3K9958V90M/Ethanol
Erratum In:
Alcohol Alcohol. 2013 Nov-Dec;48(6):745

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients.
Next Document:  Remarkable Mobility Increase and Threshold Voltage Reduction in Organic Field-Effect Transistors by ...