Document Detail


Greater regional cortical gray matter thickness in obsessive-compulsive disorder.
MedLine Citation:
PMID:  18797315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Earlier studies are inconsistent regarding the structural basis of obsessive-compulsive disorder (OCD), and few studies have investigated whether patients with OCD have cortical thickness abnormalities compared with healthy volunteers. Using magnetic resonance imaging we compared regional differences in cortical thickness among 21 patients with OCD and 21 demographically matched healthy volunteers. Our findings indicate that the right inferior frontal cortex and posterior middle temporal gyrus are thicker in patients with OCD compared with healthy controls, which may contribute to response inhibition deficits and other aspects of phenomenology related to the disorder.
Authors:
Veena M Narayan; Katherine L Narr; Owen R Phillips; Paul M Thompson; Arthur W Toga; Philip R Szeszko
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neuroreport     Volume:  19     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-17     Completed Date:  2008-11-03     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1551-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cerebral Cortex / pathology*
Female
Frontal Lobe / pathology*
Functional Laterality / physiology*
Humans
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging*
Male
Middle Aged
Obsessive-Compulsive Disorder / pathology*
Temporal Lobe / pathology*
Grant Support
ID/Acronym/Agency:
K01 MH001990/MH/NIMH NIH HHS; K01 MH001990-05/MH/NIMH NIH HHS; M01 RR018535/RR/NCRR NIH HHS; M01 RR018535/RR/NCRR NIH HHS; M01 RR018535-04/RR/NCRR NIH HHS; M01 RR018535-05/RR/NCRR NIH HHS; M01 RR018535-06/RR/NCRR NIH HHS; MH01990/MH/NIMH NIH HHS
Comments/Corrections

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