| Greater fructose consumption is associated with cardiometabolic risk markers and visceral adiposity in adolescents. | |
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MedLine Citation:
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PMID: 22190023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Though adolescents consume more fructose than any other age group, the relationship between fructose consumption and markers of cardiometabolic risk has not been established in this population. We determined associations of total fructose intake (free fructose plus one-half the intake of free sucrose) with cardiometabolic risk factors and type of adiposity in 559 adolescents aged 14-18 y. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, and C-reactive protein. Diet was assessed with 4-7 24-h recalls and physical activity (PA) was determined by accelerometry. Fat-free soft tissue (FFST) mass and fat mass were measured by DXA. The s.c. abdominal adipose tissue (SAAT) and visceral adipose tissue (VAT) were assessed using MRI. Multiple linear regression, adjusting for age, sex, race, Tanner stage, FFST mass, fat mass, PA, energy intake, fiber intake, and socioeconomic status, revealed that fructose intake was associated with VAT (β = 0.13; P = 0.03) but not SAAT (P = 0.15). Significant linear upward trends across tertiles of fructose intake were observed for systolic blood pressure, fasting glucose, HOMA-IR, and C-reactive protein after adjusting for the same covariates (all P-trend < 0.04). Conversely, significant linear downward trends across tertiles of fructose intake were observed for plasma HDL-cholesterol and adiponectin (both P-trend < 0.03). When SAAT was added as a covariate, these trends persisted (all P-trend < 0.05). However, when VAT was included as a covariate, it attenuated these trends (all P-trend > 0.05). In adolescents, higher fructose consumption is associated with multiple markers of cardiometabolic risk, but it appears that these relationships are mediated by visceral obesity. |
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Authors:
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Norman K Pollock; Vanessa Bundy; William Kanto; Catherine L Davis; Paul J Bernard; Haidong Zhu; Bernard Gutin; Yanbin Dong |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-21 |
Journal Detail:
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Title: The Journal of nutrition Volume: 142 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-23 Completed Date: 2012-03-26 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 251-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Georgia Health Sciences University, Augusta, GA, USA. npollock@georgiahealth.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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drug effects* Adolescent Biological Markers Cardiovascular Diseases / etiology* Diet Female Fructose / administration & dosage*, adverse effects* Humans Intra-Abdominal Fat / drug effects Male Metabolic Diseases / etiology* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK080887/DK/NIDDK NIH HHS; HL077230/HL/NHLBI NIH HHS; HL64157/HL/NHLBI NIH HHS; HL87923-03S1/HL/NHLBI NIH HHS; L40 HL110299/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 30237-26-4/Fructose |
| Comments/Corrections | |
Erratum In:
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J Nutr. 2013 Jan;143(1):123 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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