| Gray matter volumetric MRI differences late-preterm and term infants. | |
| | |
MedLine Citation:
|
PMID: 22285528 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Gray matter develops rapidly during the third trimester of pregnancy, which is a critical period for lipid deposition. We measured brain volume in term and late-preterm infants to determine if it is related to disabilities in late-preterm infants. In addition, we measured serum lipid concentrations to investigate the relationship between brain volume and lipid nutrition. Magnetic resonance imaging scans were obtained in 16 late-preterm and 13 term infants. We measured cerebrum, gray matter, and white matter volumes. We performed serum cholesterol, triglyceride (TG), and lipoprotein analyses in cord blood by high-performance liquid chromatography using gel permeation columns to assess lipid nutritional levels. The gray matter volume and percent cerebrum volume of gray matter were significantly smaller in late-preterm infants (p<0.001). Head circumference and cerebrum and white matter volume did not differ between the two groups. Gray matter volume correlated positively with gestational age (r=0.647, p<0.001), head circumference (r=0.688, p<0.001), and high-density lipoprotein (HDL)-TG levels (r=0.496, p=0.006). Late-preterm infants had a normal head circumference and a lower gray matter volume than term infants. Gestational age and head circumference were significantly associated with gray matter volume. Only HDL-TG levels were significantly associated with gray matter volume. HDL-TG might contribute to the transport of fatty acids and gray matter development during the postnatal period. Thus, delayed gray matter development may partly contribute to neurodevelopmental disabilities in late-preterm infants. |
| | |
Authors:
|
Shun Munakata; Tomoo Okada; Aya Okahashi; Kayo Yoshikawa; Yukihiro Usukura; Masami Makimoto; Shigeharu Hosono; Shigeru Takahashi; Hideo Mugishima; Yoshitaka Okuhata |
Related Documents
:
|
9509548 - Chorion villus sampling and limb deficiency--cause or coincidence? 17164268 - Paternal age and birth defects: how strong is the association? 14635378 - Intraventricular conduction defects in patients with congestive heart failure: left but... 10232748 - Craniosynostosis in western australia, 1980-1994: a population-based study. 14084748 - A study of some factors affecting the mortality rate in diffuse peritonitis. 11461738 - Propranolol treatment of congestive heart failure in infants with congenital heart dise... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-27 |
Journal Detail:
|
Title: Brain & development Volume: - ISSN: 1872-7131 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7909235 Medline TA: Brain Dev Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A pediatric case of reversible cerebral vasoconstriction syndrome with cortical subarachnoid hemorrh...
Next Document: Allele-selective inhibition of trinucleotide repeat genes.