Document Detail

Gray matter volume in adolescent anxiety: an impact of the brain-derived neurotrophic factor Val(66)Met polymorphism?
MedLine Citation:
PMID:  23357445     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Minimal research links anxiety disorders in adolescents to regional gray matter volume (GMV) abnormalities and their modulation by genetic factors. Prior research suggests that a brain-derived neurotrophic factor (BNDF) Val(66)Met polymorphism may modulate such brain morphometry profiles.
METHOD: Using voxel-based morphometry and magnetic resonance imaging, associations of BDNF and clinical anxiety with regional GMVs of anterior cingulate cortex, insula, amygdala, and hippocampus were examined in 39 affected (17 Met allele carriers, 22 Val/Val homozygotes) and 63 nonaffected adolescents (27 [corrected] Met allele carriers, 36 [corrected] Val/Val homozygotes).
RESULTS: Amygdala and anterior hippocampal GMVs were significantly smaller in patients than in healthy comparison adolescents, with a reverse pattern for the insula. Post-hoc regression analyses indicated a specific contribution of social phobia to the GMV reductions in the amygdala and hippocampus. In addition, insula and dorsal-anterior cingulate cortex (ACC) GMVs were modulated by BDNF genotype. In both regions, and GMVs were larger in the Val/Val homozygote patients than in individuals carrying the Met allele.
CONCLUSIONS: These results implicate reduced GMV in the amygdala and hippocampus in pediatric anxiety, particularly social phobia. In addition, the data suggest that genetic factors may modulate differences in the insula and dorsal ACC.
Sven C Mueller; Aveline Aouidad; Elena Gorodetsky; David Goldman; Daniel S Pine; Monique Ernst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Academy of Child and Adolescent Psychiatry     Volume:  52     ISSN:  1527-5418     ISO Abbreviation:  J Am Acad Child Adolesc Psychiatry     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-12-31     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8704565     Medline TA:  J Am Acad Child Adolesc Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  184-95     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Adolescent Behavior
Amino Acid Substitution
Anxiety Disorders* / genetics,  pathology
Brain / pathology*
Brain-Derived Neurotrophic Factor / genetics*
Functional Neuroimaging / methods
Genetic Predisposition to Disease
Magnetic Resonance Imaging / methods
Methionine / genetics
Organ Size
Polymorphism, Single Nucleotide
Psychiatric Status Rating Scales
Valine / genetics
Grant Support
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; AE28F7PNPL/Methionine; HG18B9YRS7/Valine
Erratum In:
J Am Acad Child Adolesc Psychiatry. 2013 Mar;52(3):329

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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