Document Detail


Gray matter heterotopias in schizophrenia.
MedLine Citation:
PMID:  7568565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gray matter heterotopias (GMHs) are a type of neuronal migration anomaly in which collections of normal neurons are abnormally located secondary to an arrest of radial migration. They are often manifested clinically by seizures and cognitive, motor, and language deficits. Through magnetic resonance imaging, we have observed two cases in patients presenting with symptoms of schizophrenia, but no neurological abnormalities, and otherwise normal scans. While the incidence of GMH among normal individuals is unknown, it is possible that this particular anomaly may occur in schizophrenic patients at a higher rate than in the normal population. Furthermore, neuronal migration abnormalities may be involved in the pathogenesis of the disorder among a small subset of patients with schizophrenia.
Authors:
P C Nopoulos; M Flaum; N C Andreasen; V W Swayze
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  61     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-11-09     Completed Date:  1995-11-09     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Diseases / complications,  diagnosis,  physiopathology*
Cell Movement*
Diagnosis, Differential
Embryonic and Fetal Development
Female
Humans
Magnetic Resonance Imaging
Male
Neurons*
Pregnancy
Prenatal Exposure Delayed Effects
Schizophrenia / etiology,  physiopathology*
Temporal Lobe / physiopathology
Grant Support
ID/Acronym/Agency:
MH-31593/MH/NIMH NIH HHS; MH-40856/MH/NIMH NIH HHS; MH-43271/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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