| Gray matter decrease distribution in the early stages of Anorexia Nervosa restrictive type in adolescents. | |
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MedLine Citation:
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PMID: 21081268 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Few studies have used Voxel-Based Morphometry (VBM) to examine brain structure in Anorexia Nervosa patients. The purpose of the present study was to investigate a sample of Anorexia Nervosa restrictive type (AN-r) adolescent patients in the early stages of the illness, using VBM in order to characterize morphometric gray matter (GM) changes. Participants were 16 AN-r female patients (with no other psychiatric disorders) whose AN-r had been in progress for less than 12months and 16 age-matched healthy female subjects. High-resolution T1-weighted magnetic resonance images were preprocessed according to the optimized VBM method, and statistically analyzed. The analyses revealed a significant global GM decrease in the AN-r patients; furthermore, a significant region-specific decrease in GM volume was found bilaterally in the middle cingulate cortex, the precuneus, and the inferior and superior parietal lobules. The significant early GM decrease in the aforementioned regions in AN-r adolescent patients suggests that there might be a region-specific GM vulnerability that could play a role in the pathophysiology of the disease. Given that these regions are also involved in the manipulation of mental images and the mental representation of the self, this might explain the presence of a distorted body image in these patients. |
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Authors:
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Santino Gaudio; Federico Nocchi; Tiziana Franchin; Elisabetta Genovese; Vittorio Cannatà; Daniela Longo; Giuseppe Fariello |
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Publication Detail:
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Type: Journal Article Date: 2010-11-16 |
Journal Detail:
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Title: Psychiatry research Volume: 191 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 24-30 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Neuroscience, Bambino Gesù Children's Hospital, Piazza S. Onofrio, 4, 00165 Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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