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Gray Matter Deficits in Panic Disorder: A Pilot Study of Meta-Analysis.
MedLine Citation:
PMID:  21508848     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: This study aimed to conduct a meta-analysis of published voxel-based morphometry studies in panic disorder (PD). METHODS:: Six data sets consisting of patients with PD and healthy controls were enrolled for this meta-analysis. A new improved voxel-based meta-analytic tool, signed differential mapping, was used to explore deficits of gray matter volume in PD patients compared to the control group. RESULTS:: Patients with PD had decreased regional gray matter volumes in right caudate head (uncorrected P = 0.0002) and right parahippocampal gyrus (uncorrected P = 0.0005). These regions could be confirmed in the following jackknife sensitivity analysis. The meta-regression results showed that the included patients with more severe PD tended to have more deficits of gray matter volume in the right basal ganglion (uncorrected P = 0.0008). CONCLUSIONS:: Patients with PD possibly have decreased gray matter volumes in the striatolimbic areas. However, more studies with whole-brain voxel-based morphometry in PD and first-episode drug-naive studies might elucidate structural deficits.
Authors:
Chien-Han Lai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-19
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  -     ISSN:  1533-712X     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Department of Psychiatry, Buddhist Tzu-Chi General Hospital, Taipei Branch; and Institute of Brain Science, National Yang Ming University, Taipei, Taiwan.
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