| Gray matter alterations in first-admission adolescents with schizophrenia. | |
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MedLine Citation:
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PMID: 20572905 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Imaging studies of patients with schizophrenia have described a variety of cerebral alterations. However, long-term medication and the chronicity of the disorder may have contributed substantially to these alterations. Studies examining patients in the early stages of the disorder reduce the possibility of such confounding factors but are rare. In light of this, the aim of the present study was to examine adolescents in the early stages of the disorder to observe primary structural brain abnormalities. METHODS: Gray and white matter were measured in 13 adolescents with schizophrenia and 13 healthy controls matched for age, gender, handedness, and school type using voxel-based morphometry. RESULTS: Subjects with schizophrenia displayed decreased gray matter in the cerebellar vermis, and alterations in the left putamen and in several parts of the visual system. CONCLUSIONS: These findings support cerebellar involvement in the pathogenesis of schizophrenia, and the alterations observed in several parts of the visual system may provide insights into the nature of hallucinations and delusional interpretations. |
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Authors:
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Romy Henze; Romuald Brunner; Ulf Thiemann; Peter Parzer; Andreas Richterich; Marco Essig; Franz Resch; Bram Stieltjes |
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Publication Detail:
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Type: Journal Article Date: 2010-06-21 |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: 241-6 Citation Subset: IM |
Copyright Information:
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© 2010 by the American Society of Neuroimaging. |
Affiliation:
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From the Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Germany (RH, RB, UT, PP, AR, FR); and Department of Radiology, German Cancer Research Center, Heidelberg, Germany (RH, ME, BS). |
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