Document Detail


Gravity-induced coating flows of vaginal gel formulations: in vitro experimental analysis.
MedLine Citation:
PMID:  15459949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Efficacy of topical microbicidal drug delivery formulations against HIV depends in part on their coating distributions and retention on vaginal epithelium. This study focused on gravity-induced coating flows of vaginal gels, and effects of formulation composition and surface wettability on coating. We hypothesized that presence of a yield stress, and surface wettability, affect coating. Experiments imaged and analyzed coating flows of gels on inclined model hydrophilic or hydrophobic surfaces. The in vitro wettability conditions bracket those believed to exist on vaginal epithelium in vivo. Six commercial vaginal gels were studied: three polyacrylic acid-based (PAA) and three cellulose-based. Our research group uses these gels in complementary human in vivo studies and other in vitro experimental analyses; this study is a first step in linking the in vivo and in vitro measurements. Coating by PAA gels was different from cellulose-based gels: the former exhibited yield stresses, which prevented initial gel shape from deforming during sliding. Coating flows of cellulose gels depended upon surface wettability. The slipping rates of the PAA gels ranked inversely with fitted yield stress values. The coating flow rates of the cellulose gels (hydrophilic surface) did not correlate with consistency index, but ranked inversely with the shear-thinning index. This study introduces a simple methodology for comparing trial formulations and relating their flows to gel constituents and physical properties. It also suggests differences in coating by current commercial gels.
Authors:
Sarah L Kieweg; Anthony R Geonnotti; David F Katz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  93     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-03     Completed Date:  2005-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2941-52     Citation Subset:  IM    
Copyright Information:
(c) 2004 Wiley-Liss, Inc. and the American Pharmacists Association
Affiliation:
Department of Biomedical Engineering, Duke University, Box 90281, Durham, North Carolina 27708, USA. sarah@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Intravaginal
Chemistry, Pharmaceutical
Drug Delivery Systems / instrumentation,  methods
Gels / chemistry*
Gravitation*
Hydrophobicity
Rheology
Surface Properties
Vaginal Creams, Foams, and Jellies / chemistry*
Viscosity
Grant Support
ID/Acronym/Agency:
R01 AI48103/AI/NIAID NIH HHS; T32 GM08555/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Gels; 0/Vaginal Creams, Foams, and Jellies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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