Document Detail

Graves' disease during pregnancy.
MedLine Citation:
PMID:  6687714     Owner:  NLM     Status:  MEDLINE    
Presented are two case studies which investigate the adverse effects of Graves' disease in pregnant women. Particular attention has been paid to the therapeutic regimen and its implications for the maternal, fetal and neonatal well-being. The first case study illustrates that Graves' disease complicating pregnancy can be treated by bed rest and careful observation of mother and fetus. The first pregnancy of our second case study confirms these results. Her second pregnancy, in which the symptoms of Graves' disease were far more severe, illustrates that it is possible to treat fetal hyperthyroidism by treating the pregnant mother with antithyroid drugs. If great care is taken to avoid overtreatment of the fetus, the treatment with antithyroid drugs is superior to surgical treatment, since surgery completely neglects the problem of fetal hyperthyroidism.
H C Kock; J M Merkus
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  14     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous / etiology
Fetal Diseases / etiology
Graves Disease / drug therapy*
Hypothyroidism / etiology
Mental Retardation / etiology
Pregnancy Complications / drug therapy*
Propylthiouracil / adverse effects
Reg. No./Substance:

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