| Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula. | |
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MedLine Citation:
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PMID: 21806011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Grassypeptolides F (1) and G (2), bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N-methylation, and a large number of d-amino acids, are reported from an extract of the Palauan cyanobacterium Lyngbya majuscula. Both 1 and 2 were found to have moderate inhibitory activity against the transcription factor AP-1 (IC₅₀ = 5.2 and 6.0 μM, respectively). |
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Authors:
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Wendy L Popplewell; Ranjala Ratnayake; Jennifer A Wilson; John A Beutler; Nancy H Colburn; Curtis J Henrich; James B McMahon; Tawnya C McKee |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2011-08-01 |
Journal Detail:
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Title: Journal of natural products Volume: 74 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-26 Completed Date: 2011-11-02 Revised Date: 2012-09-27 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1686-91 Citation Subset: IM |
Affiliation:
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Molecular Targets Laboratory, Center for Cancer Research, NCI-Frederick , Frederick, Maryland 21702-1124, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry Animals Cyanobacteria / chemistry* Depsipeptides / chemistry, isolation & purification*, pharmacology Humans Inhibitory Concentration 50 Mice Molecular Structure Nuclear Magnetic Resonance, Biomolecular Stereoisomerism Transcription Factor AP-1 / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HHSN2612008-00001E//PHS HHS; Z99 CA999999/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Depsipeptides; 0/Transcription Factor AP-1; 0/grassypeptolide F; 0/grassypeptolide G |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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