Document Detail


Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.
MedLine Citation:
PMID:  21806011     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Grassypeptolides F (1) and G (2), bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N-methylation, and a large number of d-amino acids, are reported from an extract of the Palauan cyanobacterium Lyngbya majuscula. Both 1 and 2 were found to have moderate inhibitory activity against the transcription factor AP-1 (IC₅₀ = 5.2 and 6.0 μM, respectively).
Authors:
Wendy L Popplewell; Ranjala Ratnayake; Jennifer A Wilson; John A Beutler; Nancy H Colburn; Curtis J Henrich; James B McMahon; Tawnya C McKee
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-08-01
Journal Detail:
Title:  Journal of natural products     Volume:  74     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-26     Completed Date:  2011-11-02     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1686-91     Citation Subset:  IM    
Affiliation:
Molecular Targets Laboratory, Center for Cancer Research, NCI-Frederick , Frederick, Maryland 21702-1124, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry
Animals
Cyanobacteria / chemistry*
Depsipeptides / chemistry,  isolation & purification*,  pharmacology
Humans
Inhibitory Concentration 50
Mice
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Stereoisomerism
Transcription Factor AP-1 / drug effects*
Grant Support
ID/Acronym/Agency:
HHSN2612008-00001E//PHS HHS; Z99 CA999999/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Depsipeptides; 0/Transcription Factor AP-1; 0/grassypeptolide F; 0/grassypeptolide G
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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