Document Detail


Grass roots chemistry: meta-tyrosine, an herbicidal nonprotein amino acid.
MedLine Citation:
PMID:  17940026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fine fescue grasses displace neighboring plants by depositing large quantities of an aqueous phytotoxic root exudate in the soil rhizosphere. Via activity-guided fractionation, we have isolated and identified the nonprotein amino acid m-tyrosine as the major active component. m-Tyrosine is significantly more phytotoxic than its structural isomers o- and p-tyrosine. We show that m-tyrosine exposure results in growth inhibition for a wide range of plant species and propose that the release of this nonprotein amino acid interferes with root development of competing plants. Acid hydrolysis of total root protein from Arabidopsis thaliana showed incorporation of m-tyrosine, suggesting this as a possible mechanism of phytotoxicity. m-Tyrosine inhibition of A. thaliana root growth is counteracted by exogenous addition of protein amino acids, with phenylalanine having the most significant effect. The discovery of m-tyrosine, as well as a further understanding of its mode(s) of action, could lead to the development of biorational approaches to weed control.
Authors:
Cécile Bertin; Leslie A Weston; Tengfang Huang; Georg Jander; Thomas Owens; Jerrold Meinwald; Frank C Schroeder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-10-11
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  104     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-25     Completed Date:  2007-11-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16964-9     Citation Subset:  IM    
Affiliation:
Department of Horticulture, and Boyce Thompson Institute, Cornell University, Ithaca, NY 14853, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry,  toxicity*
Arabidopsis / drug effects,  growth & development
Chemical Fractionation
Herbicides / toxicity*
Lettuce / drug effects
Plant Extracts / chemistry
Plant Roots / chemistry*,  drug effects*,  growth & development
Poaceae / chemistry*
Tyrosine / chemistry,  toxicity*
Grant Support
ID/Acronym/Agency:
GM 53830/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Herbicides; 0/Plant Extracts; 2180-37-2/3-tyrosine; 55520-40-6/Tyrosine
Comments/Corrections
Comment In:
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16729-30   [PMID:  17942678 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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