Document Detail


Graph-theoretic approach to metabolic pathways.
MedLine Citation:
PMID:  2082913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A graph-theoretic approach is shown to be applicable within the framework of the metabolic control analysis. Kinetic differential equations linearized near a steady state are presented as kinetic graphs (schemes), their structure being correlated with kinetic properties of corresponding metabolic networks. The global properties may be expressed in terms of the local properties for steady states of metabolic systems. Instability, bistability, and concentrational oscillations are shown to be induced by specific graph fragments. The approach is illustrated by an example of systems showing the oscillatory kinetic behaviour.
Authors:
B N Goldstein; V A Selivanov
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biomedica biochimica acta     Volume:  49     ISSN:  0232-766X     ISO Abbreviation:  Biomed. Biochim. Acta     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-08     Completed Date:  1991-05-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8304435     Medline TA:  Biomed Biochim Acta     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  645-50     Citation Subset:  IM    
Affiliation:
Institute of Biological Physics, USSR Academy of Sciences, Puschino, Moscow Region.
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MeSH Terms
Descriptor/Qualifier:
Biotransformation
Mathematics
Metabolism*
Models, Biological*
Oscillometry

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