Document Detail

Grape seed procyanidins in pre- and mild hypertension: a registry study.
MedLine Citation:
PMID:  24171039     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The efficacy of a standardized grape seed procyanidins extract (GSPE, Enovita) to decrease blood pressure when associated with nondrug intervention (diet and lifestyle modifications) was investigated in a controlled registry study involving 119 healthy, pre- and mildly hypertensive subjects. Two dosages of Enovita were evaluated (150 and 300 mg/die), using blood pressure and heart rate as the primary endpoints and complementing these observations with a laser Doppler flowmetry (LDF) investigation of the microcirculation state and an evaluation of the plasma oxidative status. After four months of treatment, a statistically significant higher, and dose-dependent, improvement in all endpoints was observed in the treatment groups compared to that of the control, with blood pressure normalizing in 93% of the higher dosage (300 mg) treatment group. Taken together, these observations suggest that GSPEs have beneficial cardiovascular effects that complement current intervention strategies in the hypertension area. The effect on blood pressure adds to the beneficial effects of GSPEs on the cardiovascular disease (CVD) phenotype associated with the oxidation of membrane lipids (endothelial dysfunction, formation of oxidized LDL, and activation of phagocytic cells).
Gianni Belcaro; Andrea Ledda; Shu Hu; Maria Rosa Cesarone; Beatrice Feragalli; Mark Dugall
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Publication Detail:
Type:  Journal Article     Date:  2013-09-19
Journal Detail:
Title:  Evidence-based complementary and alternative medicine : eCAM     Volume:  2013     ISSN:  1741-427X     ISO Abbreviation:  Evid Based Complement Alternat Med     Publication Date:  2013  
Date Detail:
Created Date:  2013-10-30     Completed Date:  2013-10-30     Revised Date:  2013-11-04    
Medline Journal Info:
Nlm Unique ID:  101215021     Medline TA:  Evid Based Complement Alternat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  313142     Citation Subset:  -    
Department of Biomedical Sciences, Irvine3 Circulation-Vascular Labs and San Valentino Vascular Screening Project, Gabriele D'Annunzio University, SS 16 Bis 94, Spoltore, Pescara, Italy.
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