Document Detail


Grape anaphylaxis: a study of 11 adult onset cases.
MedLine Citation:
PMID:  15813289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reports of immunoglobulin E (IgE)-mediated allergic reactions to grapes and wine are limited in the literature. Nevertheless, grapes are widely grown and consumed in Mediterranean countries. The object of this prospective study was to present clinical features, in vivo and in vitro allergy testing, and human leukocyte antigen (HLA) serotyping in patients with recurring reactions to grapes and grape products. Eleven unrelated Greek patients, six men and five women (aged 16-44 years; mean, 26.9 years) were enrolled based on a documented history of IgE-mediated reactions to grapes, wine, or other grape products. Their evaluation included full history, reaction severity, clinical examination, skin-prick tests with food allergens and molds, serum IgE, specific IgEs to the same allergen battery, and HLA typing. Patients reported 35 grape-induced anaphylaxis episodes ranging from moderate (more than one system involved but not prominent respiratory or cardiovascular symptoms; 45.5%) to severe (serious respiratory obstruction and/or hypotension and loss of consciousness; 54.5%). A causative agent was identified: wine, 10/35 (28.6%); red grapes, 9/35 (25.7%); stuffed vine leaves, 8/35 (22.9%); raisins, 3/35 (8.6%); white grapes, 2/35 (5.7%); wine vinegar, 2/35 (5. 7%); and grape juice, 1/35 (2.9%). Other foods that induced anaphylaxis were apples (54.5%), cherries (18.6%), peaches (18.6%), and bananas (9.3%). Specific IgE values were in accordance with skin-prick tests reactivity. Concerning HLA typing, 9/11 possessed HLA-DR11(5) and -DQ7(3) and the remaining two possessed HLA-DR17(3) and -DQ2 antigens. Grapes, wine and other grape products might cause serious allergic reactions in sensitized individuals. The cosensitization and reaction incidence to other fruit allergens could be a basis for further investigation of panallergens of fruits. HLA class II antigens may contribute in genetic predisposition to these allergic reactions.
Authors:
Dimitrios C Kalogeromitros; Michael P Makris; Stamatios G Gregoriou; Vassiliki G Mousatou; Nikolaos G Lyris; Katerina E Tarassi; Chryssa A Papasteriades
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  26     ISSN:  1088-5412     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-04-07     Completed Date:  2005-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
Affiliation:
Department of Allergy, University of Athens, Andreas Sygros Hospital, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anaphylaxis / blood*
Antibodies / blood
Female
Food Hypersensitivity / blood
HLA Antigens / blood*,  classification
Histocompatibility Testing
Humans
Hypersensitivity, Immediate / blood*
Immunoenzyme Techniques
Male
Skin Tests
Vitis / immunology*
Chemical
Reg. No./Substance:
0/Antibodies; 0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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