| Grape Seed Extract Alleviates High-Fat Diet-Induced Obesity and Heart Dysfunction by Preventing Cardiac Siderosis. | |
| | |
MedLine Citation:
|
PMID: 21234706 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Obesity is a tremendous public health problem, characterized by ectopic accumulation of fat into non-adipose tissues, leading to oxidative stress and chronic inflammation, in which the heart is the most severely affected organ. We used an experimental model of high-fat-diet (HFD)-induced obesity to analyze the link between oxidative stress and heart dysfunction. We also studied the cardioprotective effect of a grape seed and skin extract (GSE). Exposure of rats to HFD during 45 days induced heart hypertrophy, inflammation as assessed by plasma CRP elevation and contractile dysfunction as revealed after ischemia/reperfusion of Langendorff-perfused hearts. HFD also induced cardiac steatosis and lipotoxicity, which are linked to an oxidative stress status, worsened by increased siderosis and resulting in Ca(2+) overload. Importantly, GSE alleviated all the deleterious effects of HFD treatment. These studies suggest that GSE is a safe anti-obesity and cardioprotective agent that should also find potential applications in other inflammatory damaging conditions as stroke. |
| | |
Authors:
|
Kamel Charradi; Hichem Sebai; Salem Elkahoui; Fethy Ben Hassine; Ferid Limam; Ezzedine Aouani |
Related Documents
:
|
18403726 - Overexpression of ace2 enhances plaque stability in a rabbit model of atherosclerosis. 3841706 - Brain: body ratio and conceptional age in vascular-induced intrauterine growth retarded... 12020746 - Estriol retards and stabilizes atherosclerosis through an no-mediated system. 20416636 - Effect of an outdoor rearing system on the welfare, growth performance, carcass and mea... 3729796 - Plasma lipoproteins, apolipoproteins, and triglyceride metabolism in familial hypertrig... 11505046 - Effect of tryptophan depletion on alcohol cue-induced craving in abstinent alcoholic pa... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-14 |
Journal Detail:
|
Title: Cardiovascular toxicology Volume: - ISSN: 1559-0259 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101135818 Medline TA: Cardiovasc Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050, Hammam-lif, Tunisia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Values of Using QTc and N-Terminal Fragment of B-Type Natriuretic Peptide as Markers for Early Detec...
Next Document: Inmunohistochemical profile of solid cell nest of thyroid gland.