| Granzymes in cytolytic lymphocytes--to kill a killer? | |
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MedLine Citation:
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PMID: 15061769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Granzymes (gzm) are major components of the granules of cytolytic lymphocytes, natural killer and cytotoxic T cells. Their generally accepted mode of action consists of their directed secretion towards a virus-infected or neoplastic target cell and perforin-dependent delivery to the target cell cytosol, where they engage in various actions resulting in target cell apoptosis. Here, based on observations of infection of gzmAxB(-/-) mice with ectromelia virus, mousepox, we propose an additional--and distinct--function for gzmA and B. In this model, gzm constitute one of the first lines of defence of immune cells against virus infection of immune cells themselves. Accordingly, endogenous gzm interfere with viral replication in cytolytic lymphocytes either directly, as a result of their proteolytic activity, leading to destruction of viral proteins, or indirectly, via: (i) processes akin to the caspase cascade when acting as effector molecules in the induction of target cell apoptosis; or (ii) their capacity to induce early inflammatory mediators. We discuss the predictions of the model in the light of available data. |
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Authors:
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Matthias Regner; Arno Müllbacher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunology and cell biology Volume: 82 ISSN: 0818-9641 ISO Abbreviation: Immunol. Cell Biol. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-05 Completed Date: 2004-11-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8706300 Medline TA: Immunol Cell Biol Country: Australia |
Other Details:
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Languages: eng Pagination: 161-9 Citation Subset: IM |
Affiliation:
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Molecular Immunology and Immunopathology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia. Matthias.Regner@anu.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology Granzymes Humans Serine Endopeptidases / metabolism* T-Lymphocytes, Cytotoxic / enzymology, immunology, metabolism* Virus Physiological Phenomena Virus Replication / physiology Viruses / immunology* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.-/GZMB protein, human; EC 3.4.21.-/Granzymes; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.78/GZMA protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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