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Granzymes A and B levels in serum of patients with amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  21349256     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives There are evidence that immuno-inflammatory mechanisms and apoptosis may play a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). It is known that Granzyme A (GzmA) and granzyme B (GzmB) are implicated in these mechanisms. The aim of the study was to investigate serum GzmA and GzmB levels in patients with ALS. MATERIALS AND METHODS: The study included 30 patients with ALS and 30 patients from the control group. Serum GzmA and GzmB levels were measured using the enzyme-linked immunosorbent method. RESULTS: The study showed that GzmA and GzmB levels are significantly increased in serum of patients with ALS when compared to the control group (p<0.05). There was a significant correlation of serum GzmB levels with severity of clinical state of ALS patients (p<0.05). CONCLUSION: The results indicate that GzmA and GzmB are implicated in mechanisms of neurodegeneration in ALS.
Authors:
Joanna Iłżecka
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-21
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier Inc.
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