Document Detail


Granulomatous uveitis and congenital cataract: a rare association.
MedLine Citation:
PMID:  20408081     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The association of a granulomatous uveitis and congenital cataract and is rarely observed in newborn children. We describe the history of two patients presenting simultaneously with these two features in the absence of a TORCH infection. PATIENTS AND METHODS: The first patient, a boy born in 1997, presented to our hospital two days after birth with multiples Koeppe's and Busacca's nodules and bilateral cataract. The second patient, a boy born in 2006, was referred two weeks after birth. He presented with a severe unilateral granulomatous uveitis, multiples iris nodules, a high intraocular pressure of 45 mmHg and a congenital cataract. THERAPY AND OUTCOME: Lens extraction produced a rapid resolution of uveitis in these two patients. TORCH infection was ruled out in both children by history, extensive serologies performed simultaneously in mother and child or PCR of ocular fluids. CONCLUSIONS: A congenital cataract associated with a granulomatous uveitis is an extremely rare association. The removal of the lens resulted in complete resolution of the inflammation: a phacogenic mechanism could be at the origin of ocular inflammation in both cases.
Authors:
A Basso; K Mansouri; B E Frueh; Y Guex-Crosier
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-04-20
Journal Detail:
Title:  Klinische Monatsbl?tter f?r Augenheilkunde     Volume:  227     ISSN:  1439-3999     ISO Abbreviation:  Klin Monbl Augenheilkd     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014133     Medline TA:  Klin Monbl Augenheilkd     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  306-8     Citation Subset:  IM    
Copyright Information:
Copyright Georg Thieme Verlag KG Stuttgart . New York.
Affiliation:
Jules-Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Cataract / congenital*,  diagnosis*,  therapy
Granuloma / congenital*,  diagnosis*,  therapy
Humans
Infant
Male
Rare Diseases / congenital,  diagnosis,  therapy
Uveitis / congenital*,  diagnosis*,  therapy

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