Document Detail

Granulomatous inflammation in nevi undergoing regression (halo phenomenon): a report of 6 cases.
MedLine Citation:
PMID:  18496423     Owner:  NLM     Status:  MEDLINE    
Halo phenomenon is a process whereby a melanocytic nevus undergoes regression with or without a clinically evident halo. It is now well established that cell-mediated immunity and to a lesser extent humoral immunity are integral to the development of halo nevi. We report 6 cases of nevi exhibiting halo phenomenon with granulomatous inflammation received in our dermatopathology practice over a 7-month period. Of these 6 cases, clinical evidence of a halo was documented in 2 of the nevi. In none of the cases was there a mention of granulomatous inflammation by the referring pathologist. Despite an extensive review of the literature, we did not find a report of overtly granulomatous inflammation occurring in regressing nevi, although we encounter the phenomenon not uncommonly in our practice and believe that practicing dermatopathologists should be aware of it.
Kwame Sekou Denianke; Geoffrey J Gottlieb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  30     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-22     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  233-5     Citation Subset:  IM    
Ackerman Academy of Dermatopathology, New York, NY, USA.
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MeSH Terms
Antigens, CD / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Granuloma / immunology,  pathology*
Inflammation / immunology,  pathology
Lymphocytes / pathology
Melanocytes / pathology
Middle Aged
Neoplasm Regression, Spontaneous*
Nevus, Pigmented / immunology,  pathology*
S100 Proteins / analysis
Skin Neoplasms / immunology,  pathology*
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/S100 Proteins

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