Document Detail


Granulomatous inflammation in nevi undergoing regression (halo phenomenon): a report of 6 cases.
MedLine Citation:
PMID:  18496423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Halo phenomenon is a process whereby a melanocytic nevus undergoes regression with or without a clinically evident halo. It is now well established that cell-mediated immunity and to a lesser extent humoral immunity are integral to the development of halo nevi. We report 6 cases of nevi exhibiting halo phenomenon with granulomatous inflammation received in our dermatopathology practice over a 7-month period. Of these 6 cases, clinical evidence of a halo was documented in 2 of the nevi. In none of the cases was there a mention of granulomatous inflammation by the referring pathologist. Despite an extensive review of the literature, we did not find a report of overtly granulomatous inflammation occurring in regressing nevi, although we encounter the phenomenon not uncommonly in our practice and believe that practicing dermatopathologists should be aware of it.
Authors:
Kwame Sekou Denianke; Geoffrey J Gottlieb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  30     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-22     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  233-5     Citation Subset:  IM    
Affiliation:
Ackerman Academy of Dermatopathology, New York, NY, USA. kdeniank@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Child
Female
Granuloma / immunology,  pathology*
Humans
Inflammation / immunology,  pathology
Lymphocytes / pathology
Male
Melanocytes / pathology
Middle Aged
Neoplasm Regression, Spontaneous*
Nevus, Pigmented / immunology,  pathology*
S100 Proteins / analysis
Skin Neoplasms / immunology,  pathology*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/S100 Proteins

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