Document Detail

Granulomatous endometritis associated with histologically occult cytomegalovirus in a healthy patient.
MedLine Citation:
PMID:  1326899     Owner:  NLM     Status:  MEDLINE    
This report describes the case of a 32-year-old female with chronic pelvic pain who was otherwise in good health. Endocervical curettings contained rare cells with intranuclear and cytoplasmic inclusions characteristic of cytomegalovirus (CMV) infection. Endometrial curettings demonstrated a stromal lymphocytic and plasmacytic infiltrate as well as numerous small, non-necrotizing granulomas, but no CMV by microscopic examination. However, CMV was identified by the polymerase chain reaction in DNA extracted from a paraffin section of the endometrial tissue. In conjunction with previous reports, the clinical and pathologic features of this case suggest that CMV can cause chronic endometritis in nonimmunocompromised patients. Furthermore, CMV infection should be considered in the differential diagnosis of granulomatous endometritis. This case demonstrates the usefulness of using the polymerase chain reaction to detect CMV in paraffin-embedded material.
T S Frank; K S Himebaugh; M D Wilson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  16     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-10-16     Completed Date:  1992-10-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  716-20     Citation Subset:  IM    
Department of Pathology, University of Michigan Medical School, Ann Arbor.
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MeSH Terms
Cytomegalovirus / isolation & purification*
Cytomegalovirus Infections / complications*,  pathology
Electrophoresis, Agar Gel
Endometritis / etiology*,  pathology
Endometrium / microbiology
Granuloma / pathology
Polymerase Chain Reaction
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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