Document Detail

Granulomatous colitis of boxer dogs.
MedLine Citation:
PMID:  21486645     Owner:  NLM     Status:  In-Data-Review    
Granulomatous colitis (GC) is a rare, breed-specific inflammatory bowel disease of young Boxer dogs. GC has been refractory to treatment and associated with high mortality rates, but culture-independent molecular analysis has transformed therapy and prognosis by uncovering a correlation between GC and Escherichia coli invasion within colonic mucosal macrophages. GC-associated invasive E coli are similar to a newly identified E coli pathotype, "adherent and invasive E coli," that are increasingly associated with Crohn's disease in humans. Successful treatment of GC requires antimicrobials that are effective against E coli and penetrate intracellularly. Enrofloxacin is widely regarded as the antibiotic of choice.
Melanie Craven; Caroline S Mansfield; Kenneth W Simpson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Veterinary clinics of North America. Small animal practice     Volume:  41     ISSN:  1878-1306     ISO Abbreviation:  Vet. Clin. North Am. Small Anim. Pract.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7809942     Medline TA:  Vet Clin North Am Small Anim Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  433-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Veterinary Clinical Sciences, Cornell University, Tower Road, Ithaca, NY 14853-6401, USA.
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