| Granulomatous colitis of boxer dogs. | |
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MedLine Citation:
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PMID: 21486645 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Granulomatous colitis (GC) is a rare, breed-specific inflammatory bowel disease of young Boxer dogs. GC has been refractory to treatment and associated with high mortality rates, but culture-independent molecular analysis has transformed therapy and prognosis by uncovering a correlation between GC and Escherichia coli invasion within colonic mucosal macrophages. GC-associated invasive E coli are similar to a newly identified E coli pathotype, "adherent and invasive E coli," that are increasingly associated with Crohn's disease in humans. Successful treatment of GC requires antimicrobials that are effective against E coli and penetrate intracellularly. Enrofloxacin is widely regarded as the antibiotic of choice. |
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Authors:
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Melanie Craven; Caroline S Mansfield; Kenneth W Simpson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Veterinary clinics of North America. Small animal practice Volume: 41 ISSN: 1878-1306 ISO Abbreviation: Vet. Clin. North Am. Small Anim. Pract. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7809942 Medline TA: Vet Clin North Am Small Anim Pract Country: United States |
Other Details:
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Languages: eng Pagination: 433-45 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Veterinary Clinical Sciences, Cornell University, Tower Road, Ithaca, NY 14853-6401, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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