Document Detail

Granulomatous arteritis with massive eosinophilic leukocyte infiltration and transient peripheral eosinophilia subsequent to transarterial embolization therapy with a gelatin sponge.
MedLine Citation:
PMID:  1750358     Owner:  NLM     Status:  MEDLINE    
A 38-year-old man presented with a cavernous hemangioma in the liver. Transarterial embolization (TAE) using a gelatin sponge was carried out 14 days prior to surgical resection of the tumor. Granulomatous arteritis with massive infiltration by eosinophilic leukocytes and histiocytes was present at the periphery of the hemangioma, and transient eosinophilia in the peripheral blood occurred six days after resection. Granulomatous arteritis was evident in medium-sized arteries and there was narrowing or occlusion of the vascular lumen. In the granulomatous cellular infiltrates in the arteries, giant cells of the foreign body type were numerous. An eosinophilic substance differing from fibrin was present in some of the vascular lumina. As this showed staining for collagen, it was considered likely to be fragments of the gelatin sponge. The patient had no symptoms of fever, chills or general fatigue. The clinical course and pathologic findings suggest a causative role of the gelatin sponge in this case of granulomatous arteritis. Vascular change, a rare complication of TAE therapy, may be induced by a hypersensitivity reaction against the intra-arterial gelatin sponge.
H Ishikura; Y Sotozaki; H Adachi; M Sato; T Yoshiki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  41     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-01-17     Completed Date:  1992-01-17     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  618-22     Citation Subset:  IM    
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Arteritis / blood*,  etiology,  physiopathology
Cell Movement / physiology
Embolization, Therapeutic / adverse effects*
Eosinophilia / etiology,  pathology*,  physiopathology
Gelatin Sponge, Absorbable / adverse effects*,  therapeutic use
Hemangioma / pathology,  therapy
Hypersensitivity / pathology
Leukocytes / pathology*
Liver Neoplasms / pathology,  therapy

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