| Granulomatous Pneumocystis jiroveci pneumonia in a patient with diffuse large B-cell lymphoma: case report and review of the literature. | |
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MedLine Citation:
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PMID: 19940467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here we report a case of diffuse large B-cell lymphoma who developed granulomatous Pneumocystis jiroveci pneumonia (PJP) after rituximab and combination chemotherapy. The infection presented as a solitary pulmonary nodule (SPN) instead of the commonly seen diffuse ground-glass infiltrates. The diagnosis was made by wedge resection of the nodule. Both the CD4+ lymphocyte count and immunoglobulin level were low. A literature search revealed 14 granulomatous PJP patients with hematological neoplasms, including the present case, which was the first with diffuse large B-cell lymphoma and the only patient receiving rituximab before PJP development. In addition to our report, only one case had previously presented with an SPN. Our experience suggests that granulomatous PJP should be considered a possible etiology when immunocompromised patients develop fever and SPNs. |
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Authors:
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Hung Chang; Lee-Yung Shih; Chi-Wei Wang; Wen-Yu Chuang; Chien-Cheng Chen |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-11-25 |
Journal Detail:
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Title: Acta haematologica Volume: 123 ISSN: 1421-9662 ISO Abbreviation: Acta Haematol. Publication Date: 2010 |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 30-3 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 S. Karger AG, Basel. |
Affiliation:
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Division of Hematology-Oncology, Chang Gung University School of Medicine, Chang Gung Memorial Hospital, 5 Fu-Shing Street, Kweishan,Taoyuan, Taiwan (ROC). |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies, Monoclonal / therapeutic use Antineoplastic Combined Chemotherapy Protocols / therapeutic use Granuloma, Respiratory Tract / diagnosis, etiology Humans Lymphoma, Large B-Cell, Diffuse / complications*, therapy Male Opportunistic Infections / diagnosis, etiology* Pneumocystis jirovecii* Pneumonia, Pneumocystis / diagnosis, etiology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/rituximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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