Document Detail


Granulomatosis-associated common variable immunodeficiency disorder: a case-control study versus sarcoidosis.
MedLine Citation:
PMID:  22903958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to investigate to what extent interstitial lung disease (ILD) in common variable immunodeficiency disorder (CVID)-associated granulomatous disease (GD) is similar to pulmonary sarcoidosis 20 patients with CVID/GD were included in a retrospective study conducted by the Groupe Sarcoïdose Francophone. Medical records were centralised. Patients were compared with 60 controls with sarcoidosis. Clinical examination showed more frequent crackles in patients than controls (45% versus 1.7%, respectively; p<0.001). On thoracic computed tomography scans, nodules (often multiple and with smooth margins), air bronchograms and halo signs were more frequent in patients than controls (80% versus 42%, respectively; p=0.004) as well as bronchiectasis (65% versus 23%, respectively; p<0.001). The micronodule distribution was perilymphatic in 100% of controls and in 42% of patients (p<0.001). Bronchoalveolar lavage analysis showed lower T-cell CD4/CD8 ratios in patients than in controls (mean ± sd 1.6 ± 1.1 versus 5.3 ± 4, respectively; p<0.01). On pathological analysis, nodules and consolidations corresponded to granulomatous lesions with or without lymphocytic disorders in most cases. Mortality was higher in patients than controls (30% versus 0%, respectively) and resulted from common variable immunodeficiency complications. ILD in CVID/GD presents a specific clinical picture and evolution that are markedly different from those of sarcoidosis.
Authors:
Diane Bouvry; Luc Mouthon; Pierre-Yves Brillet; Marianne Kambouchner; Jean-Pierre Ducroix; Vincent Cottin; Julien Haroche; Jean-Francois Viallard; Romain Lazor; François Lebargy; Abdellatif Tazi; Benoît Wallaert; Amar Smail; Jean-Luc Pellegrin; Hilario Nunes; Zahir Amoura; Jean-François Cordier; Dominique Valeyre; Jean-Marc Naccache;
Related Documents :
19914688 - Increased thrombin generation in inflammatory bowel diseases.
19661218 - Increased efficiency of hemodialysis with citrate dialysate: a prospective controlled s...
1489978 - Primary sclerosing cholangitis: an analysis of 37 retrospective cases.
22500908 - Poincaré plot indexes of heart rate variability detect dynamic autonomic modulation du...
24570478 - Survival of patients with anca-associated vasculitis on chronic dialysis: data from the...
17410288 - Glycogen storage disease type i--between chronic ambulatory follow-up and pediatric eme...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-08-16
Journal Detail:
Title:  The European respiratory journal     Volume:  41     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-13     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  115-22     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Case-Control Studies
Child
Common Variable Immunodeficiency / complications,  diagnosis*
Female
Granuloma / complications,  diagnosis*
Humans
Lung Diseases, Interstitial / complications,  diagnosis*
Male
Middle Aged
Retrospective Studies
Sarcoidosis, Pulmonary / diagnosis*
Young Adult
Comments/Corrections
Comment In:
Eur Respir J. 2014 Mar;43(3):922-4   [PMID:  24585875 ]
Eur Respir J. 2014 Mar;43(3):924-5   [PMID:  24585876 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hemodynamic responses to exercise in patients with COPD.
Next Document:  Smoking and asthma: dangerous liaisons.