Document Detail

Granuloma formation by muramyl dipeptide associated with branched fatty acids, a structure probably essential for tubercle formation by Mycobacterium tuberculosis.
MedLine Citation:
PMID:  3924828     Owner:  NLM     Status:  MEDLINE    
Muramyl dipeptide, which does not induce epithelioid granuloma when injected alone dissolved in phosphate-buffered saline, could induce extensive granulomas in guinea pigs when chemically conjugated with branched, but not linear, fatty acids. Peptidoglycan fragments of Staphylococcus epidermidis could evoke epithelioid granulomas when incorporated in a water-in-oil emulsion. These findings suggest the importance of a lipid bound to muramyl dipeptide for granuloma formation. In view of the fact that mycobacteria uniquely contain large amounts of branched fatty acids, it was proposed that the complex of muramyl dipeptide and branched fatty acids, mostly mycolic acids, is a structure in tubercle bacilli responsible for tubercle formation.
K Emori; S Nagao; N Shigematsu; S Kotani; M Tsujimoto; T Shiba; S Kusumoto; A Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection and immunity     Volume:  49     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-05     Completed Date:  1985-08-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-9     Citation Subset:  IM    
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MeSH Terms
Fatty Acids*
Granuloma / chemically induced*,  pathology
Guinea Pigs
Mycobacterium tuberculosis / pathogenicity*
Staphylococcus epidermidis / pathogenicity
Structure-Activity Relationship
Reg. No./Substance:
0/Fatty Acids; 53678-77-6/Acetylmuramyl-Alanyl-Isoglutamine
Erratum In:
Infect Immun 1986 Apr;52(1):348

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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