| Granuloma formation by muramyl dipeptide associated with branched fatty acids, a structure probably essential for tubercle formation by Mycobacterium tuberculosis. | |
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MedLine Citation:
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PMID: 3924828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Muramyl dipeptide, which does not induce epithelioid granuloma when injected alone dissolved in phosphate-buffered saline, could induce extensive granulomas in guinea pigs when chemically conjugated with branched, but not linear, fatty acids. Peptidoglycan fragments of Staphylococcus epidermidis could evoke epithelioid granulomas when incorporated in a water-in-oil emulsion. These findings suggest the importance of a lipid bound to muramyl dipeptide for granuloma formation. In view of the fact that mycobacteria uniquely contain large amounts of branched fatty acids, it was proposed that the complex of muramyl dipeptide and branched fatty acids, mostly mycolic acids, is a structure in tubercle bacilli responsible for tubercle formation. |
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Authors:
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K Emori; S Nagao; N Shigematsu; S Kotani; M Tsujimoto; T Shiba; S Kusumoto; A Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infection and immunity Volume: 49 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-05 Completed Date: 1985-08-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 244-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylmuramyl-Alanyl-Isoglutamine* Animals Fatty Acids* Female Granuloma / chemically induced*, pathology Guinea Pigs Mycobacterium tuberculosis / pathogenicity* Staphylococcus epidermidis / pathogenicity Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 53678-77-6/Acetylmuramyl-Alanyl-Isoglutamine |
| Comments/Corrections | |
Erratum In:
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Infect Immun 1986 Apr;52(1):348 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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