Document Detail

Granuloma annulare.
MedLine Citation:
PMID:  19169208     Owner:  NLM     Status:  MEDLINE    
AIM: Granuloma annulare (GA) is a palisading granulomatous skin disease. It is a relatively common dermatosis typically characterized by an annular arrangement of erythematous or flesh-coloured papules. The aim of this study was to assess the epidemiological and clinical pattern of GA and its management.
METHODS: A retrospective study dealing with 35 cases of GA collected during an 11-year period from 1995 to 2005 was carried out at the Dermatology Department of Charles Nicolle's Hospital of Tunis.
RESULTS: There were 24 females and 11 males including 13 children. Four clinical patterns were observed: localized GA with annular shaped lesions in 22 cases (62.8%), subcutaneous GA in 9 cases (25.7%) with 4 children, combination of localized and subcutaneous patterns in one child (2.8%), generalized GA in one adult-patient (2.8%) and combination of generalized and subcutaneous patterns in 2 cases (5.7%). Associated diabetes mellitus was seen in 9 adults (25%) and thyroid diseases in 2 other adults (5.7%). Topical steroids were proposed in 9 cases with partial resolution in 6 of them. Four patients were treated by hydroxychloroquine with an improvement in 3 of them. Two patients (generalized GA with subcutaneous form and subcutaneous GA) were treated by dapsone with partial clearing.
CONCLUSION: In these series, GA has the same epidemiological and clinical pattern as other series of the literature. Subcutaneous form had a pseudo-rheumatoid presentation in adults and an exclusive involvement of children when it is localized on the scalp. Associated systemic diseases, especially diabetes mellitus, are frequent in the series here observed.
S Goucha; A Khaled; M Kharfi; B Fazaa; R Zermani; S Ben Jilani; M R Kamoun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia     Volume:  143     ISSN:  0392-0488     ISO Abbreviation:  G Ital Dermatol Venereol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-04-03     Revised Date:  2012-07-30    
Medline Journal Info:
Nlm Unique ID:  8102852     Medline TA:  G Ital Dermatol Venereol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  359-63     Citation Subset:  IM    
Department of Dermatology, Charles Nicolle hospital of Tunis, Tunisia.
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MeSH Terms
Administration, Cutaneous
Adrenal Cortex Hormones / administration & dosage
Anti-Infective Agents / administration & dosage
Antirheumatic Agents / administration & dosage
Child, Preschool
Dapsone / administration & dosage
Diabetes Complications / drug therapy
Diabetes Mellitus, Type 1 / complications
Diabetes Mellitus, Type 2 / complications
Drug Therapy, Combination
Granuloma Annulare / complications,  diagnosis,  drug therapy*,  epidemiology,  pathology*
Hydroxychloroquine / administration & dosage
Middle Aged
Retrospective Studies
Rheumatic Diseases / etiology
Risk Factors
Thyroid Diseases / complications
Treatment Outcome
Tunisia / epidemiology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Infective Agents; 0/Antirheumatic Agents; 118-42-3/Hydroxychloroquine; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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