| Granuloma annulare. | |
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MedLine Citation:
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PMID: 19169208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Granuloma annulare (GA) is a palisading granulomatous skin disease. It is a relatively common dermatosis typically characterized by an annular arrangement of erythematous or flesh-coloured papules. The aim of this study was to assess the epidemiological and clinical pattern of GA and its management. METHODS: A retrospective study dealing with 35 cases of GA collected during an 11-year period from 1995 to 2005 was carried out at the Dermatology Department of Charles Nicolle's Hospital of Tunis. RESULTS: There were 24 females and 11 males including 13 children. Four clinical patterns were observed: localized GA with annular shaped lesions in 22 cases (62.8%), subcutaneous GA in 9 cases (25.7%) with 4 children, combination of localized and subcutaneous patterns in one child (2.8%), generalized GA in one adult-patient (2.8%) and combination of generalized and subcutaneous patterns in 2 cases (5.7%). Associated diabetes mellitus was seen in 9 adults (25%) and thyroid diseases in 2 other adults (5.7%). Topical steroids were proposed in 9 cases with partial resolution in 6 of them. Four patients were treated by hydroxychloroquine with an improvement in 3 of them. Two patients (generalized GA with subcutaneous form and subcutaneous GA) were treated by dapsone with partial clearing. CONCLUSION: In these series, GA has the same epidemiological and clinical pattern as other series of the literature. Subcutaneous form had a pseudo-rheumatoid presentation in adults and an exclusive involvement of children when it is localized on the scalp. Associated systemic diseases, especially diabetes mellitus, are frequent in the series here observed. |
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Authors:
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S Goucha; A Khaled; M Kharfi; B Fazaa; R Zermani; S Ben Jilani; M R Kamoun |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia Volume: 143 ISSN: 0392-0488 ISO Abbreviation: G Ital Dermatol Venereol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-04-03 Revised Date: 2012-07-30 |
Medline Journal Info:
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Nlm Unique ID: 8102852 Medline TA: G Ital Dermatol Venereol Country: Italy |
Other Details:
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Languages: eng Pagination: 359-63 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Charles Nicolle hospital of Tunis, Tunisia. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adolescent Adrenal Cortex Hormones / administration & dosage Adult Anti-Infective Agents / administration & dosage Antirheumatic Agents / administration & dosage Child Child, Preschool Dapsone / administration & dosage Diabetes Complications / drug therapy Diabetes Mellitus, Type 1 / complications Diabetes Mellitus, Type 2 / complications Drug Therapy, Combination Female Granuloma Annulare / complications, diagnosis, drug therapy*, epidemiology, pathology* Humans Hydroxychloroquine / administration & dosage Infant Male Middle Aged Retrospective Studies Rheumatic Diseases / etiology Risk Factors Thyroid Diseases / complications Treatment Outcome Tunisia / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Infective Agents; 0/Antirheumatic Agents; 118-42-3/Hydroxychloroquine; 80-08-0/Dapsone |
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