Document Detail

Granuloma annulare: an elastic tissue disease? Case report and literature review.
MedLine Citation:
PMID:  10086915     Owner:  NLM     Status:  MEDLINE    
Granuloma annulare (GA) is a condition characterized by the presence of palisading granulomas usually in the dermis. Traditionally, the histopathological changes are described as consisting of focal degeneration of dermal collagen fibers. However, no convincing evidence for such alteration is found in the literature. A histopathological study was done to ascertain the nature of the dermal abnormality. Ten skin biopsies showing lesions of GA were studied by light and electron microscopy. On light microscopy, all lesions showed focal dermal degeneration with near total loss of elastic fibers. Ultrastructural examination in nine cases demonstrated degenerated elastic fibers with loss of peripheral microfibrils and abnormal elastic matrix. The degenerated elastic fibers were surrounded by intact collagen fibers. These findings show that the main alteration in GA is elastic fiber degeneration and strongly suggest that the primary target leading to the development of this disorder is injury to the elastic tissue.
W M Hanna; F Moreno-Merlo; L Andrighetti
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Ultrastructural pathology     Volume:  23     ISSN:  0191-3123     ISO Abbreviation:  Ultrastruct Pathol     Publication Date:    1999 Jan-Feb
Date Detail:
Created Date:  1999-04-30     Completed Date:  1999-04-30     Revised Date:  2009-06-26    
Medline Journal Info:
Nlm Unique ID:  8002867     Medline TA:  Ultrastruct Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  IM    
Women's College Hospital, The University of Toronto, Ontario, Canada.
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MeSH Terms
Connective Tissue Diseases / pathology
Elastic Tissue / pathology,  ultrastructure
Granuloma Annulare / pathology*
Middle Aged
Skin / pathology,  ultrastructure*
Comment In:
Ultrastruct Pathol. 1999 Nov-Dec;23(6):407   [PMID:  10626692 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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