Document Detail


Granulocytic sarcoma of abdomen in acute myeloid leukemia patient with inv(16) and t(6;17) abnormal chromosome: case report and review of literature.
MedLine Citation:
PMID:  20116851     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Granulocytic sarcoma (GS) is composed of immature granulocytic precursors and is usually found in acute myeloid leukemia (AML) patients with t(8;21). Inv(16) is rarely associated with GS comparing with t(8;21) leukemia. Here we describe an abdominal GS patient in AML-M2 with acquired translocation between chromosomes 6 and 17 and inv (16). We have also summarized 20 reported GS cases with inv(16) and found that chloroma was most often found in abdominal lesions. Intestine maybe a tissue specific target for the expression of inv(16) leukemia. Complete physical examination and molecular diagnosis are necessary for AML patients to benefit from the diagnosis and therapeutic strategy.
Authors:
Xu-Hui Zhang; Ri Zhang; Yanfen Li
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-02-08
Journal Detail:
Title:  Leukemia research     Volume:  34     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  958-61     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Soochow, Jiangsu, PR China. xhzhang2828@yahoo.cn
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MeSH Terms
Descriptor/Qualifier:
Abdominal Neoplasms / drug therapy,  genetics*,  pathology
Acute Disease
Adolescent
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chromosome Inversion*
Chromosomes, Human, Pair 16 / ultrastructure*
Chromosomes, Human, Pair 17 / ultrastructure*
Chromosomes, Human, Pair 6 / ultrastructure*
Cytarabine / administration & dosage
Humans
Idarubicin / administration & dosage
Leukemia, Myeloid, Acute / drug therapy,  genetics*,  pathology
Male
Remission Induction
Sarcoma, Myeloid / drug therapy,  genetics*,  pathology
Translocation, Genetic*
Chemical
Reg. No./Substance:
147-94-4/Cytarabine; 58957-92-9/Idarubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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