Document Detail

Granulocytic sarcoma of abdomen in acute myeloid leukemia patient with inv(16) and t(6;17) abnormal chromosome: case report and review of literature.
MedLine Citation:
PMID:  20116851     Owner:  NLM     Status:  MEDLINE    
Granulocytic sarcoma (GS) is composed of immature granulocytic precursors and is usually found in acute myeloid leukemia (AML) patients with t(8;21). Inv(16) is rarely associated with GS comparing with t(8;21) leukemia. Here we describe an abdominal GS patient in AML-M2 with acquired translocation between chromosomes 6 and 17 and inv (16). We have also summarized 20 reported GS cases with inv(16) and found that chloroma was most often found in abdominal lesions. Intestine maybe a tissue specific target for the expression of inv(16) leukemia. Complete physical examination and molecular diagnosis are necessary for AML patients to benefit from the diagnosis and therapeutic strategy.
Xu-Hui Zhang; Ri Zhang; Yanfen Li
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-02-08
Journal Detail:
Title:  Leukemia research     Volume:  34     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  958-61     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Soochow, Jiangsu, PR China.
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MeSH Terms
Abdominal Neoplasms / drug therapy,  genetics*,  pathology
Acute Disease
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chromosome Inversion*
Chromosomes, Human, Pair 16 / ultrastructure*
Chromosomes, Human, Pair 17 / ultrastructure*
Chromosomes, Human, Pair 6 / ultrastructure*
Cytarabine / administration & dosage
Idarubicin / administration & dosage
Leukemia, Myeloid, Acute / drug therapy,  genetics*,  pathology
Remission Induction
Sarcoma, Myeloid / drug therapy,  genetics*,  pathology
Translocation, Genetic*
Reg. No./Substance:
147-94-4/Cytarabine; 58957-92-9/Idarubicin

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