| Granulocytic sarcoma of abdomen in acute myeloid leukemia patient with inv(16) and t(6;17) abnormal chromosome: case report and review of literature. | |
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MedLine Citation:
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PMID: 20116851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Granulocytic sarcoma (GS) is composed of immature granulocytic precursors and is usually found in acute myeloid leukemia (AML) patients with t(8;21). Inv(16) is rarely associated with GS comparing with t(8;21) leukemia. Here we describe an abdominal GS patient in AML-M2 with acquired translocation between chromosomes 6 and 17 and inv (16). We have also summarized 20 reported GS cases with inv(16) and found that chloroma was most often found in abdominal lesions. Intestine maybe a tissue specific target for the expression of inv(16) leukemia. Complete physical examination and molecular diagnosis are necessary for AML patients to benefit from the diagnosis and therapeutic strategy. |
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Authors:
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Xu-Hui Zhang; Ri Zhang; Yanfen Li |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2010-02-08 |
Journal Detail:
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Title: Leukemia research Volume: 34 ISSN: 1873-5835 ISO Abbreviation: Leuk. Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 958-61 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Soochow, Jiangsu, PR China. xhzhang2828@yahoo.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Neoplasms
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drug therapy,
genetics*,
pathology Acute Disease Adolescent Antineoplastic Combined Chemotherapy Protocols / therapeutic use Chromosome Inversion* Chromosomes, Human, Pair 16 / ultrastructure* Chromosomes, Human, Pair 17 / ultrastructure* Chromosomes, Human, Pair 6 / ultrastructure* Cytarabine / administration & dosage Humans Idarubicin / administration & dosage Leukemia, Myeloid, Acute / drug therapy, genetics*, pathology Male Remission Induction Sarcoma, Myeloid / drug therapy, genetics*, pathology Translocation, Genetic* |
| Chemical | |
Reg. No./Substance:
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147-94-4/Cytarabine; 58957-92-9/Idarubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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