Document Detail


Granulocytic sarcoma: 32 cases and review of the literature.
MedLine Citation:
PMID:  17169797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-two cases of granulocytic sarcoma (GS) are reported in this paper. Age range was from 16 - 70 years. GS was accompanied by AML in 13 cases, ALL (My+) in one case, CML in 11 cases and MDS in two cases. GS was diagnosed simultaneously with leukemia in five cases and preceded the leukemia in eight. Lymph node and soft tissue were the most commonly detected localizations. Seven cases had first been diagnosed as NHL. Histopathologically blastic, immature and mature variants were found in 11, nine and 11 cases respectively and overall survival was shortest in the blastic type. Myeloperoxidase and lysozyme were found to be positive in 30 and 24 cases respectively. Therapy was radiation in five cases and surgery in three. Systemic chemotherapy was given to the cases. The clinical outcome of the patients after the diagnosis of GS was poor. GS is a unique entity; prognosis is poor but it is important to detect the signaling pathways associated with migration of myeloid cells to the extra-medullary tissues. The critical factors for detecting this interesting tumor are to be aware of this disease, cooperation between clinician and pathologist and the application of special stains to detect the myeloid origin.
Authors:
Semra Paydas; Suzan Zorludemir; Melek Ergin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  47     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-09-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  2527-41     Citation Subset:  IM    
Affiliation:
Department of Oncology, Cukurova University Faculty of Medicine, Adana, Turkey. sepay@cu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biopsy
Diagnosis, Differential
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / therapy
Lymphoma, Non-Hodgkin / therapy
Male
Medical Oncology / methods
Middle Aged
Sarcoma, Myeloid / diagnosis*
Stem Cell Transplantation
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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