Document Detail

Granulocytes in bronchial lavage fluid after major vascular surgery.
MedLine Citation:
PMID:  3644586     Owner:  NLM     Status:  MEDLINE    
Increased numbers of polymorphonuclear granulocytes (PMN) in the airways, as measured by PMN content in bronchial lavage fluid (P less than 0.01), were found 3 h postoperatively in ten patients undergoing surgery for lumbar aortic aneurysms. An increase in plasma levels of the complement split product C3dg from 6 (0-19) AU/ml preoperatively to 20 (13-50) AU/ml 3 h after surgery (P less than 0.01), indicates an activation of the complement cascade. These changes were not accompanied by increased elastase activity in the bronchial lavage fluid or by major changes in pulmonary blood gas exchange or vascular resistance, indicating that massive PMN activation, analogous to that proposed in adult respiratory distress syndrome (ARDS) had not taken place. In conclusion, complement system activation and migration of PMN into the airways, as seen in connection with major vascular surgery, does not seem to contribute to ARDS-type pulmonary dysfunction.
E Fosse; H Opdahl; S Sunde; A O Aasen; J L Svennevig
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  31     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-04-15     Completed Date:  1987-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
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MeSH Terms
Aorta, Abdominal
Aortic Aneurysm / surgery*
Bronchi / cytology*
Cell Count
Complement C3b / analysis
Lung / physiology
Middle Aged
Neutrophils / cytology*,  enzymology
Pancreatic Elastase / metabolism
Peptide Fragments / analysis
Postoperative Period
Reg. No./Substance:
0/Peptide Fragments; 0/complement C3d,g; 80295-43-8/Complement C3b; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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