Document Detail


Granulocyte transfusions in neonates with bacterial infection, neutropenia, and depletion of mature marrow neutrophils.
MedLine Citation:
PMID:  7088606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During a three-year period, 26 neonates with bacterial infection and neutropenia were studied. In order to assess the marrow neutrophil reserves, bone marrow aspirates were obtained from each of these patients. The neutrophil storage pool (percent polymorphonuclear + band neutrophils + metamyelocytes in 1,000 nucleated marrow cells) was significantly greater in those who survived their infection (mean = 20.1%, range 3.2% to 60.8%) than in those who died (mean = 1.9%, range 0.4% to 5.2%, P less than .002). In an attempt to improve survival in this group, seven neutrophil-depleted patients with sepsis were given granulocyte transfusions and all survived. In contrast only one of nine nontransfused and all survived. In contrast only one of nine nontransfused, neutrophil-depleted infants with sepsis survived (P less than .01). The seven granulocyte recipients were examined for possible adverse effects of the transfusions and none were detected. It is suggested that infected, neutropenic neonates with depletion of mature marrow neutrophils are at high risk for death from sepsis, and that these infants may benefit from granulocyte transfusion therapy.
Authors:
R D Christensen; G Rothstein; H B Anstall; B Bybee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  70     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Agranulocytosis / therapy*
Bacterial Infections / blood,  pathology,  therapy*
Blood Transfusion*
Bone Marrow / pathology
Granulocytes / transplantation*
Humans
Infant, Newborn
Infant, Newborn, Diseases / blood,  pathology,  therapy*
Leukocyte Count
Neutropenia / pathology,  therapy*
Neutrophils / pathology
Grant Support
ID/Acronym/Agency:
AM-07115/AM/NIADDK NIH HHS; HD-14419-01A1/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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