Document Detail

Granulocyte transfusion: current status.
MedLine Citation:
PMID:  17198843     Owner:  NLM     Status:  MEDLINE    
Infection associated with therapy-related neutropenia continues to be a major cause of morbidity and mortality. Renewed interest in granulocyte transfusion therapy as treatment for this condition has been generated by the observation that large doses of granulocytes can be obtained from donors who have been stimulated with granulocyte colony-stimulating factor (G-CSF). Granulocytes collected from these donors have been shown to effectively raise the patient's neutrophil count and appear to function normally as judged both by in vitro and in vivo measures. The evidence for clinical efficacy is limited to that of case reports and small series, and the results are not uniform. Randomized controlled clinical trials are needed to determine whether this therapy is useful in either clearing infections or prolonging survival.
Thomas H Price
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in hematology     Volume:  44     ISSN:  0037-1963     ISO Abbreviation:  Semin. Hematol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-02     Completed Date:  2007-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404514     Medline TA:  Semin Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-23     Citation Subset:  IM    
Puget Sound Blood Center and Department of Medicine, University of Washington, Seattle, WA 98104, USA.
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MeSH Terms
Case-Control Studies
Granulocyte Colony-Stimulating Factor / therapeutic use*
Leukapheresis / methods*
Leukocyte Transfusion / adverse effects*
Treatment Outcome
Reg. No./Substance:
143011-72-7/Granulocyte Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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