Document Detail

Granulocyte-macrophage progenitor cells in term and preterm neonates.
MedLine Citation:
PMID:  3783329     Owner:  NLM     Status:  MEDLINE    
In groups of adults, and term and preterm neonates, we determined: the blood concentration, the proliferative rate, and the variety of progeny of committed granulocyte-macrophage progenitor cells (CFU-GM). In five of eight term neonates and in all premature infants, a potentially significant limitation of neutrophil production was detected. Unlike the slowly proliferating CFU-GM present in the blood of healthy adult subjects (7% thymidine suicide, range 0% to 32%), the circulating CFU-GM in the premature subjects were proliferating at a near maximal rate (55%, range 40% to 75%, P less than 0.001). Because CFU-GM proliferation is nearly maximal in the baseline, noninfected state, neonates may have restricted ability to increase neutrophil production from CFU-GM during times of increased neutrophil need, such as during bacterial infection. Such inability may predispose neonates to exhaustion of the neutrophil supply during bacterial infection.
R D Christensen; T E Harper; G Rothstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  109     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1986-12-29     Completed Date:  1986-12-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1047-51     Citation Subset:  AIM; IM    
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MeSH Terms
Colony-Forming Units Assay
Fetal Blood / analysis
Granulocytes / analysis*
Hematopoietic Stem Cells / analysis*
Infant, Newborn / blood*
Infant, Premature / blood*
Macrophages / analysis*
Grant Support

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