Document Detail

Granulocyte independence of pulmonary oxygen toxicity in the rat.
MedLine Citation:
PMID:  2743954     Owner:  NLM     Status:  MEDLINE    
The role of neutrophils in the mediation of severe normobaric hyperoxic lung injury has been studied by monitoring the effects of neutrophil depletion on a rat model of pulmonary oxygen toxicity. Pulmonary capillary permeability, assessed using an [125I]albumin lung permeability index (LPI), progressively increased with an increased duration of hyperoxia exposure in normal animals (LPI = 0.43 +/- 0.09 at 24 h; 0.95 +/- 0.17 at 48 h; 1.56 +/- 0.21 at 60 h), despite the absence of any significant tissue or bronchoalveolar lavage evidence of neutrophil infiltration until 60 h of hyperoxia exposure. Neutrophil depletion (using cyclophosphamide) blocked this late neutrophil infiltrate but failed to attenuate lung injury (LPI = 0.38 +/- 0.06 at 24 h; 0.89 +/- 0.16 at 48 h; 1.58 +/- 0.10 at 60 h; all p greater than .05 compared with leucocyte-replete/normal animals exposed to hyperoxia). The temporal dissociation of pulmonary neutrophil accumulation and pulmonary injury and the failure of effective neutrophil depletion to abrogate hyperoxic lung injury indicate that neutrophil polymorphs play no substantive role in the mediation of tissue injury in this model of severe pulmonary oxygen toxicity.
N W Boyce; D Campbell; S R Holdsworth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental lung research     Volume:  15     ISSN:  0190-2148     ISO Abbreviation:  Exp. Lung Res.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-08-11     Completed Date:  1989-08-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-8     Citation Subset:  IM; S    
Department of Medicine, Monash University, Prince Henry's Hospital, Melbourne, Victoria, Australia.
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MeSH Terms
Cyclophosphamide / pharmacology
Granulocytes / drug effects,  metabolism,  physiology*
Lung Diseases / immunology*,  metabolism
Oxygen / toxicity*
Rats, Inbred Strains
Reg. No./Substance:
50-18-0/Cyclophosphamide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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