| Granulocyte independence of pulmonary oxygen toxicity in the rat. | |
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MedLine Citation:
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PMID: 2743954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of neutrophils in the mediation of severe normobaric hyperoxic lung injury has been studied by monitoring the effects of neutrophil depletion on a rat model of pulmonary oxygen toxicity. Pulmonary capillary permeability, assessed using an [125I]albumin lung permeability index (LPI), progressively increased with an increased duration of hyperoxia exposure in normal animals (LPI = 0.43 +/- 0.09 at 24 h; 0.95 +/- 0.17 at 48 h; 1.56 +/- 0.21 at 60 h), despite the absence of any significant tissue or bronchoalveolar lavage evidence of neutrophil infiltration until 60 h of hyperoxia exposure. Neutrophil depletion (using cyclophosphamide) blocked this late neutrophil infiltrate but failed to attenuate lung injury (LPI = 0.38 +/- 0.06 at 24 h; 0.89 +/- 0.16 at 48 h; 1.58 +/- 0.10 at 60 h; all p greater than .05 compared with leucocyte-replete/normal animals exposed to hyperoxia). The temporal dissociation of pulmonary neutrophil accumulation and pulmonary injury and the failure of effective neutrophil depletion to abrogate hyperoxic lung injury indicate that neutrophil polymorphs play no substantive role in the mediation of tissue injury in this model of severe pulmonary oxygen toxicity. |
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Authors:
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N W Boyce; D Campbell; S R Holdsworth |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental lung research Volume: 15 ISSN: 0190-2148 ISO Abbreviation: Exp. Lung Res. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-08-11 Completed Date: 1989-08-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 491-8 Citation Subset: IM; S |
Affiliation:
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Department of Medicine, Monash University, Prince Henry's Hospital, Melbourne, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cyclophosphamide / pharmacology Granulocytes / drug effects, metabolism, physiology* Lung Diseases / immunology*, metabolism Male Oxygen / toxicity* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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50-18-0/Cyclophosphamide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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