Document Detail

Granulocyte Macrophage-Colony Stimulating Factor receptor expression on human cardiomyocytes from end-stage heart failure patients.
MedLine Citation:
PMID:  16480924     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In remodelling ventricles, the progression of heart failure is associated with structural changes involving the extra-cellular matrix (ECM) and the cytoskeleton of cardiomyocytes, associated with fibrosis, cellular damage and death. The role of some cytokines and haematopoietic growth factors in the mechanism of both damage and regeneration of cardiac tissue during acute myocardial infarction has been demonstrated. Following heart damage, the development of scarred tissue was considered to be the only outcome, since myocytes were considered to be terminally differentiated cells. However, recent studies in animal models and adult human hearts have shown that myocytes can proliferate under the modulation of several factors.
AIMS: To assess Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) receptor expression in healthy and diseased human hearts, and to evaluate the possible role of GM-CSF and its receptor in the regeneration of cardiac tissue in chronic cardiomyopathy.
METHODS AND RESULTS: GM-CSFR expression in human cardiac tissue from explanted hearts of ten patients with end-stage heart failure and in cardiac biopsies from eight normal human hearts was studied by immunohistochemistry, and cellular and molecular biology assays. Our results demonstrated an increase in GM-CSFR in cardiomyocytes from end-stage heart failure tissues as compared to normal control tissues.
CONCLUSIONS: We hypothesize that GM-CSF plays a role in apoptotic and/or ECM deposition processes as well as in cytoskeleton modification in the myocardium.
Loredana Postiglione; Stefania Montagnani; Paolo Ladogana; Clotilde Castaldo; Gaetano Di Spigna; Eugenia Maria Bruno; Mimmo Turano; Luca De Santo; Giuseppe Cudemo; Sergio Cocozza; Oreste de Divitiis; Guido Rossi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-09
Journal Detail:
Title:  European journal of heart failure     Volume:  8     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-02-27     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  564-70     Citation Subset:  IM    
Department of Cellular and Molecular Biology and Pathology "L. Califano", "Federico II" University, Via S. Pansini, 5, Ed. 19, 80131 Naples, Italy.
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MeSH Terms
Biological Assay
Cardiomyopathy, Dilated / physiopathology*
Disease Progression
Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis*
Middle Aged
Myocardial Infarction / physiopathology*
Myocytes, Cardiac / pathology*
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis*
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

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